ABSTRACT
ABSTRACT: Giant cell tumor of bone (GCT) is a benign tumor of bone that is known to be locally aggressive rarely metastasizing to distant sites, most commonly to the lungs. The reported pulmonary metastasis incidence is 1 - 9%. We report a case of GCT with solitary pulmonary metastasis who had significant clinical benefit and disease control with sequential application of surgical resection of pulmonary metastasis, local external beam radiation therapy (EBRT), and systemic Denosumab. We wish to highlight that even in metastatic GCT, there is significant clinical benefit in aggressive treatment.
Subject(s)
Bone Neoplasms , Giant Cell Tumor of Bone , Lung Neoplasms , Humans , Lung Neoplasms/pathology , Lung Neoplasms/secondary , Lung Neoplasms/therapy , Giant Cell Tumor of Bone/pathology , Giant Cell Tumor of Bone/therapy , Giant Cell Tumor of Bone/secondary , Giant Cell Tumor of Bone/diagnosis , Bone Neoplasms/secondary , Bone Neoplasms/therapy , Bone Neoplasms/pathology , Adult , Female , Femur/pathology , Femur/diagnostic imaging , Femur/surgery , Treatment Outcome , Male , Denosumab/therapeutic use , Combined Modality TherapySubject(s)
Acute Kidney Injury/etiology , Cardiac Surgical Procedures/adverse effects , Contrast Media/adverse effects , Acute Kidney Injury/prevention & control , Angioplasty, Balloon, Coronary/adverse effects , Humans , Intraoperative Care , Postoperative Care , Postoperative Complications/etiologyABSTRACT
We report the case of a patient who needed mitral valve replacement but was at a high risk of myocardial injury with the conventional technique (cardioplegic arrest on cardiopulmonary bypass). Valve replacement was carried out on a beating heart on cardiopulmonary bypass by perfusing the heart continuously with oxygenated noncardioplegic normothermic blood via the coronary sinus.
Subject(s)
Heart Valve Prosthesis Implantation/methods , Mitral Valve Insufficiency/surgery , Mitral Valve/surgery , Adolescent , Female , HumansABSTRACT
The case report describes a difficult and not uncommon situation of a patient suffering from an evolving myocardial infarction with hemodynamic instability along with a critical bilateral extracranial carotid artery stenosis. A technique of retrograde coronary sinus perfusion was used to temporarily stabilize the cardiac status while the carotid lesion was being tackled.
