[Effect of misoprostol, a synthetic prostaglandin E analog, on levels of serum C-peptide in serum and glucose tolerance]. / Wplyw misoprostolu, syntetycznego odpowiednika prostaglandyny E1, na stezenie peptydu C w surowicy krwi i tolerancje glukozy.

The aim of the study was to investigate whether oral application of misoprostol (MI), which is an analogue of prostaglandin E1, does change the secretion of insulin and the blood glucose level. The investigations were carried out in 15 subjects, aged 21-40 yrs, with a gastric or duodenal ulcer and without any disturbances of the digestive tract motility. In 7 of them (group A), without stated diabetes a single oral dose of 400 mg MI versus placebo (PL) and 15 min later 75 g glucose p.o., was applied in randomized order, on different days, in fasting state. In 8 subjects with mild diabetes type II (gr B) MI versus PL and after 15 min. i.v. 1.0 mg glucagon was similarly administered. In both groups the concentrations of glucose and C-peptide in blood were determined. In comparison to PL, the application of MI did not cause any statistically significant differences of C-peptide in serum and blood glucose levels neither before and after oral glucose loading nor after i.v. administration of glucagon. Statistically not significant were also the differences in AUC (p > 0.05).

[Usefulness of determining the blood protein synthesis index in the evaluation of liver damage]. / Przydatnosc oznaczania wskaznika syntezy bialek osocza krwi w ocenie uszkodzenia watroby.

UNLABELLED: The purpose of report was the presentation of the variability range of the plasma protein synthesis index (PSI) in dependence on the chronic character of the liver parenchyma lesion in man or the extent of parallel indices of PSI with other biochemical parameters usually determined in the diagnostics of the liver parenchyma diseases. The studies have been performed in 20 patients with viral hepatitis (VH ), 20 patients with balanced liver cirrhosis (BLC), 20 patients with unbalanced liver cirrhosis and in 43 healthy volunteers. The PSI, total protein, albumin, gamma-globulin, bilirubin, prothrombin index and the alanine aminotransferase and the choline esterase activity has been determined. The most important lowering of the PSI values has been observed in patients with BLC. In those with VH the prolonged depression of the protein synthesis may indicate the chronic character of the inflammatory process. The extent of correlation of PSI with other parameters was statistically not significant. CONCLUSIONS: 1. PSI is a result of the liver lesion and its values are lowest in patients with MWN. 2. The WSB value does not depend on the age of subjects studied. 3. The diagnostic usefulness of WSB for evaluation of the liver parenchyma lesion is greater than of the albumin, choline esterase or prothrombin index determination. 4. The WSB determination is of value in the complex evaluation of the liver function in patients with lesions of that organ.