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Cancer Chemother Pharmacol ; 7(2-3): 93-8, 1982.
Article in English | MEDLINE | ID: mdl-7044596

ABSTRACT

The unique biological properties and therapeutic efficacy of the podophyllotoxin derivatives, Vumon (VM26, teniposide) and Vepesid (VP16-213, etoposide), are stimulating the interest of both laboratory and clinical researchers. Investigations on new pharmaceutical formulations, pharmacokinetics and metabolism are providing more appropriate information in drug administration; experimental chemotherapy indicates that, among others, cytosine arabinoside and cisplatin are highly synergistic with podophyllotoxins; single agent and combination treatment clinical trials are defining the respective role of Vumon and Vepesid in cancer chemotherapy.


Subject(s)
Etoposide/pharmacology , Podophyllotoxin/analogs & derivatives , Teniposide/metabolism , Teniposide/pharmacology , Chemistry, Pharmaceutical , Drug Compounding , Drug Stability , Drug Synergism , Drug Therapy, Combination , Etoposide/metabolism , Humans , Kinetics
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