Personality pathology and drinking in young men at high and low familial risk for alcoholism.

OBJECTIVE: Three groups varying in familial alcoholism risk were compared with respect to amount of alcohol consumption, presence of personality pathology, and the relationship between personality pathology and alcohol consumption. METHOD: Research subjects were young adult men recruited from local colleges, a trade school and the community. The risk groups included (1) a group with a biological alcoholic father and significant additional familial alcoholism (n = 106); (2) subjects with an alcoholic father, but without significant additional familial alcoholism (n = 100); and (3) a group with no paternal alcoholism and at most only one second/third-degree alcoholic relative (n = 190). Absolute daily ounces of alcohol was determined using a standard quantity-frequency scale. Prevalence of DSM-III-R personality disorders (PDs) was evaluated using the Personality Disorder Questionnaire-Revised both with and without application of an impairment and distress scale. Familial risk determination was based on agreement between four separate self-report assessments. RESULTS: The first group consumed significantly more alcohol than the other two groups, which did not differ in alcohol consumption. The first group's subjects were more likely to meet criteria for virtually all of the PD diagnoses than were the other two groups. A greater proportion of the second group's subjects qualified for various PDs than did the third group's subjects. Personality pathology was consistently or usually associated with more drinking in the first and third groups, respectively, but associated with less consumption in the second group. CONCLUSIONS: Young men with high-density familial alcoholism are at greater risk for the development of alcoholism than those with alcoholic fathers and little additional familial alcoholism. Relationships between personality pathology and alcohol consumption, and possibly the development of alcoholism, differ for the three risk groups.

Reducing waiting time for substance abuse treatment does not reduce attrition.

Attrition rates from substance abuse treatment are high. In an attempt to cut down on the attrition rate in our clinic we instituted an "Orientation Group" to cut down on the time patients spent waiting to enter treatment. An evaluation of the results of this intervention reveals that contrary to the impressions of the clinical staff, the attrition rate was not reduced.

Relationship between lactate dehydrogenase and myeloperoxidase levels in human gingival crevicular fluid and clinical and microbial measurements.

The present study was designed to determine, in a cross-sectional study, whether there was any relationship between levels of lactate dehydrogenase (LDH) and myeloperoxidase (MPO) in gingival crevicular fluid (GCF) and clinical periodontal status or microbial parameters. Another objective was to determine, in a longitudinal study, the effect of a single session of root planning on GCF levels of LDH and MPO and the relation to changes in clinical and microbial measurements. 15 and 12 test subjects with moderate to severe periodontal disease were seen in the cross-sectional and longitudinal study, respectively. 1 healthy and 2 diseased sites were evaluated in each subject. Higher LDH and MPO levels in GCF were closely associated with higher clinical and microbial signs of periodontal disease. Root planing was effective in reducing these enzymes in GCF, with an accompanying decrease in clinical and microbial signs associated with disease. The return of LDH to baseline levels at 3 months after instrumentation, without a corresponding return of clinical signs of disease, may serve as a marker for subclinical periodontal pathology.

Correlation of aphakic retinal detachment and refractive error with gender.

I analyzed the aphakic refractive errors of men and women separately in a statistical study of patients with aphakic retinal detachments. I compared the distribution of aphakic refractive errors in a population of 81 adult patients with nontraumatic aphakic retinal detachment with that of a randomly selected control population of 93 adult patients with aphakia. As a group, women who developed aphakic retinal detachments were significantly more myopic than female controls (11.41 vs 12.37 diopters of spherical equivalent; P = .004). In contrast, the refractive error in men did not differ between the aphakic retinal detachment and control groups (11.31 vs 11.68 diopters; P = .156). A significantly higher percentage of patients with bilateral (87%) aphakic retinal detachments were men (P = .017). In men other risk factors for aphakic retinal detachment, including cardiovascular disease, may overshadow the influence of axial myopia.