ABSTRACT
Ten keratoacanthomas with both proliferative and regressive histologic features along with 10 well-differentiated squamous cell carcinomas were examined using immunohistochemistry for the expression of bcl-2, a protooncogene recently recognized to be involved in protecting cells from undergoing apoptosis. The squamous cell carcinomas had a modest but diffuse staining pattern, while the proliferative keratoacanthomas stained only at the basal cells and only rare cells stained positively in the regressive keratoacanthomas. The degree and pattern of staining suggest a loss of bcl-2 expression with tumor maturity in keratoacanthoma and a possible role in their ultimate involution.
Subject(s)
Carcinoma, Squamous Cell/chemistry , Keratoacanthoma/classification , Proto-Oncogene Proteins/analysis , Skin Neoplasms/chemistry , Humans , Immunohistochemistry , Proto-Oncogene Proteins/genetics , Proto-Oncogene Proteins c-bcl-2ABSTRACT
A case of scrotal and penile extramammary Paget's disease (EMPD) and concurrent prostate adenocarcinoma in a 59-year-old patient is presented. Immunohistochemically, the tumor cells of both the EMPD and prostate stained positively for prostate-specific antigen. Six previously reported cases of EMPD associated with prostate adenocarcinoma are reviewed, along with a discussion of current theories of the pathogenesis of EMPD.
Subject(s)
Adenocarcinoma/pathology , Genital Neoplasms, Male/pathology , Neoplasms, Multiple Primary/pathology , Paget Disease, Extramammary/pathology , Prostatic Neoplasms/pathology , Carcinoembryonic Antigen/analysis , Humans , Male , Middle Aged , Prostate-Specific Antigen/analysis , S100 Proteins/analysisABSTRACT
Heightened public and professional awareness of the sexual abuse of children demands that physicians be able to distinguish lesions associated with sexual abuse from those caused by primary skin disorders. Purpura is an occasional manifestation of pediatric lichen sclerosus et atrophicus (LSA), especially when the vulva is affected. We report a 12-year-old boy with penile purpura that occasioned a consideration of sexual abuse but proved to be due to LSA.
Subject(s)
Lichenoid Eruptions/complications , Penile Diseases/etiology , Pigmentation Disorders/complications , Purpura/etiology , Child , Humans , Lichenoid Eruptions/diagnosis , Lichenoid Eruptions/drug therapy , Male , Penile Diseases/diagnosis , Pigmentation Disorders/diagnosis , Pigmentation Disorders/drug therapy , Purpura/diagnosisABSTRACT
An 8-year-old girl had pseudoxanthoma elasticum (PXE) with the characteristic skin and ocular findings. She had no associated systemic symptoms and no family history of PXE. The disease was most likely inherited in an autosomal recessive fashion. It is reviewed with regard to etiology, inheritance, diagnosis, and, particularly, management.
Subject(s)
Pseudoxanthoma Elasticum/diagnosis , Biopsy , Child , Female , Humans , Pseudoxanthoma Elasticum/complications , Pseudoxanthoma Elasticum/genetics , Pseudoxanthoma Elasticum/therapy , Retinal Diseases/etiology , Skin/pathology , Vascular Diseases/etiologyABSTRACT
A pyogenic granuloma occurred in a port-wine stain treated with first an argon, and subsequently a carbon dioxide, laser. Although reports of this phenomenon are infrequent in the literature, our review suggests that this is not a rare complication. The pathogenetic implications are discussed.
Subject(s)
Granuloma/etiology , Hemangioma/surgery , Laser Therapy/adverse effects , Skin Diseases/etiology , Skin Neoplasms/surgery , Adult , Female , Granuloma/surgery , Hemangioma/etiology , Humans , Skin Diseases/surgery , Skin Neoplasms/etiology , SuppurationABSTRACT
A neonate had numerous positive skin cultures for herpes simplex virus (HSV) as well as associated abnormalities strongly suggestive of a maternal intrauterine infection. In addition, he was noted to have dystrophic calcinosis cutis involving the back and buttocks. We believe the dystrophic calcinosis cutis occurred as a consequence of the HSV infection.