ABSTRACT
A patient with non-Hodgkin's lymphoma was treated by ambulant lymphocytapheresis once a month over a period of 2 years and 8 months. The cytoreductive effect resulted in a decrease of white blood cells from 410/nl to 130/nl. The patient tolerated the procedure, which lasted 3-4 h, without any side effects. He could be kept in good condition by monthly apheresis. So lymphocytapheresis is a means to reduce hyperleukocytosis in patients with non-Hodgkin's lymphoma.
Subject(s)
Leukapheresis , Leukemia, Lymphocytic, Chronic, B-Cell/therapy , Leukocytosis/therapy , Lymphocyte Depletion , Ambulatory Care , Humans , Leukemia, Lymphocytic, Chronic, B-Cell/blood , Leukocyte Count , Leukocytosis/blood , Male , Middle AgedABSTRACT
Apart from a slight hemolysis at very low flow rates, the peristaltic infusion pump IVAC 560 has no harmful effects on blood components such as packed red cells, whole blood, platelet concentrates and fresh frozen plasma. So it may be a convenient option to perform volume processed transfusions.
Subject(s)
Blood Cell Count , Blood Chemical Analysis , Blood Component Transfusion/instrumentation , Blood Transfusion/instrumentation , Infusion Pumps , Plasma , Pulsatile Flow , Blood Coagulation Tests , Blood Flow Velocity/physiology , Hemoglobinometry , HumansABSTRACT
Stored serum samples from 7,179 nonselected blood donors were tested for anti-HCV using Ortho EIA first generation. Results were compared to data acquired by anti-HBc testing and ALT levels found in routine testing. 24 donors (0.33%) were repeatedly reactive with Ortho HCV EIA, 230 (3.20%) were anti-HBc-positive and 138 (1.92%) had raised ALT levels > or = 36 IU/l. A low correlation was found between HCV antibody screening with EIA and surrogate testing. When tested in addition with the Abbott HCV EIA, 20 of the 24 Ortho EIA-positive subjects showed a positive reaction. In the Abbott neutralization test 13 of these 20 (65%) were reactive. 8 (33.33%) of the 24 Ortho-EIA-positive donors were positive in the two-antigen-RIBA (first generation), 8 were indeterminate and 8 were nonreactive. The neutralization test and the RIBA can be used as supplementary tests fo further analyze HCV-EIA-positive specimens.
