Development and Implementation of the Data Science Learning Platform for Research Physician.

Data analysis and their application are the unavoidable factors in the activities analyses in health care. Unfortunately, the acquisition of data from large available medical databases is a complex process and requires deep knowledge of computer science and especially knowledge of tools for data management. According to the European General Data Protection Regulation, the problem becomes much more complex. Recognizing these problems and difficulties, we have developed a Data Science Learning Platform (DSLP) that primarily targets practitioners and researchers but also the computer science students. Using our proposed tool chain together with the developed graphical user interface, data scientists and research physicians will be able to use available medical databases, apply and analyze different anonymization methods, analyze data according to the patient's risk and quickly formulate new studies to target a disease in a complex data model. This article presents a clinical research discovery toolbox that implements and demonstrates tools for data anonymization, patient data visualization, NLP-tools for guideline search and data science learning tools.

A Visualization and Benchmarking Simulator for Clinical Data.

The availability of Big Data has increased significantly in many areas in recent years. Insights from these data sets lead to optimized processes in many industries, which is why understanding as well as gaining knowledge through analyses of these data sets is becoming increasingly relevant. In the medical field, especially in intensive care units, fast and appropriate treatment is crucial due to the usually critical condition of patients. The patient data recorded here is often very heterogeneous and the resulting database models are very complex, so that accessing and thus using this data requires technical background knowledge. We have focused on the development of a web application that is primarily aimed at clinical staff and researchers. It is an easily accessible visualization and benchmarking tool that provides a graphical interface for the MIMIC-III database. The anonymized datasets contained in MIMIC-III include general information about patients as well as characteristics such as vital signs and laboratory measurements. These datasets are of great interest because they can be used to improve digital decision support systems and clinical processes. Therefore, in addition to visualization, the application can be used by researchers to validate anomaly detection algorithms and by clinical staff to assess disease progression. For this purpose, patient data can be individualized through modifications such as increasing and decreasing vital signs and laboratory parameters so that disease progression can be simulated and subsequently analyzed according to the user's specific needs.

Dermatology Disease Prediction Based on Two Step Cascade Genetic Algorithm Optimization of ANFIS Parameters.

The aim of this study is to present novel algorithms for prediction of dermatological disease using only dermatological clinical features and diagnoses collected in real conditions. A combination of the Adaptive Neuro-Fuzzy Inference Systems (ANFIS) and Genetic algorithm (GA) for ANFIS subtractive clustering parameter optimization has been suggested for the first level of fuzzy model optimization. After that, a genetic optimized ANFIS fuzzy structure is used as input in GA for the second level of fuzzy model optimization. We used double 2-fold Cross validation for generating different validation sets for model improvements. Our approach is performed in the MATLAB environment. We compared results with the other studies. The results confirm that the proposed model achieves accuracy rates which are higher than the one with the previous model.

Prediction of Heart Attack Risk Using GA-ANFIS Expert System Prototype.

The aim of this research is to develop a novel GA-ANFIS expert system prototype for classifying heart disease degree of a patient by using heart diseases attributes (features) and diagnoses taken in the real conditions. Thirteen attributes have been used as inputs to classifiers being based on Adaptive Neuro-Fuzzy Inference Systems (ANFIS) for the first level of fuzzy model optimization. They are used as inputs in Genetic Algorithm (GA) for the second level of fuzzy model optimization within GA-ANFIS system. GA-ANFIS system performs optimization in two steps. Modelling and validating of the novel GA-ANFIS system approach is performed in MATLAB environment. We compared GA-ANFIS and ANFIS results. The proposed GA-ANFIS model with the predicted value technique is more efficient when diagnosis of heart disease is concerned, as well the earlier method we got by ANFIS model.

GA-ANFIS Expert System Prototype for Prediction of Dermatological Diseases.

This paper presents novel GA-ANFIS expert system prototype for dermatological disease detection by using dermatological features and diagnoses collected in real conditions. Nine dermatological features are used as inputs to classifiers that are based on Adaptive Neuro-Fuzzy Inference Systems (ANFIS) for the first level of fuzzy model optimization. After that, they are used as inputs in Genetic Algorithm (GA) for the second level of fuzzy model optimization within GA-ANFIS system. GA-ANFIS system performs optimization in two steps. Modelling and validation of the novel GA-ANFIS system approach is performed in MATLAB environment by using validation set of data. Some conclusions concerning the impacts of features on the detection of dermatological diseases were obtained through analysis of the GA-ANFIS. We compared GA-ANFIS and ANFIS results. The results confirmed that the proposed GA-ANFIS model achieved accuracy rates which are higher than the ones we got by ANFIS model.

Detection of nicotine content impact in tobacco manufacturing using computational intelligence.

A study is presented for the detection of nicotine impact in different cigarette type, using recorded data and Computational Intelligence techniques. Recorded puffs are processed using Continuous Wavelet Transform and used to extract time-frequency features for normal and abnormal puffs conditions. The wavelet energy distributions are used as inputs to classifiers based on Adaptive Neuro-Fuzzy Inference Systems (ANFIS) and Genetic Algorithms (GAs). The number and the parameters of Membership Functions are used in ANFIS along with the features from wavelet energy distributionare selected using GAs, maximising the diagnosis success. GA with ANFIS (GANFIS) are trained with a subset of data with known nicotine conditions. The trained GANFIS are tested using the other set of data (testing data). A classical method by High-Performance Liquid Chromatography is also introduced to solve this problem, respectively. The results as well as the performances of these two approaches are compared. A combination of these two algorithms is also suggested to improve the efficiency of this solution procedure. Computational results show that this combined algorithm is promising.

Optimized detection of tar content in the manufacturing process using adaptive neuro-fuzzy inference systems.

The purpose of this study is to model and optimize the detection of tar in cigarettes during the manufacturing process and show that low yield cigarettes contain similar levels of nicotine as compared to high yield cigarettes while B (Benzene), T(toluene) and X (xylene) (BTX) levels increase with increasing tar yields. A neuro-fuzzy system which comprises a fuzzy inference structure is used to model such a system. Given a training set of samples, the Adaptive Neuro-Fuzzy Inference System (ANFIS) classifiers learned how to differentiate a new case in the domain. The ANFIS classifiers were used to detect the tar in smoke condensate when five basic features defining cigarette classes indications were used as inputs. A classical method by High Performance Liquid Chromatography (HPLC) is also introduced to solve this problem. At last the performances of these two methods are compared.