ABSTRACT
The effect of N-acetylcysteine (NAC), on the UVB-induced inhibition of epidermal DNA synthesis in rat skin was investigated. Topical application of NAC, 30 min prior to UVB irradiation (20 kJ m-2), significantly reduced the UVB-induced inhibition of the epidermal (methyl-1',2'-3H)-thymidine uptake. These results indicate that NAC affords protection against at least some of the damaging effects of UVB radiation on epidermal DNA, probably by neutralization of UVB induced reactive species.
Subject(s)
Acetylcysteine/pharmacology , DNA/radiation effects , Skin/radiation effects , Ultraviolet Rays , Animals , DNA/biosynthesis , DNA/drug effects , DNA Replication/drug effects , DNA Replication/radiation effects , Dose-Response Relationship, Radiation , Female , Rats , Rats, Wistar , Skin/drug effects , Skin/metabolismABSTRACT
Synopsis With high-performance liquid chromatography the three major isomers present in the sunscreen agent, 5(3, 3-dimethyl-2-norbornylidene)-3 pentene-2-one, have been isolated and quantified. Their structures have been determined using mass, infra-red, and NMR spectrometry. Isomères dans le filtre solaire 5(3, 3-dimethyl-2-norbornylidene)-3 pentene-2-one.