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Appl Radiat Isot ; 66(2): 252-60, 2008 Feb.
Article in English | MEDLINE | ID: mdl-17933545

ABSTRACT

A blind performance test was conducted to evaluate dose-calibrator measurements at nuclear pharmacies in the United States (US). Two test-sample geometries were chosen to represent those used for measurements of 90Y-ibritumomab tiuxetan (ZEVALIN). The radioactivity concentration of test-samples was verified by the US National Institute of Standards and Technology. Forty-five results were reported by 10 participants. Eighty percent of reported values were within the US Pharmacopoeia content standard (+/-10%) for 90Y-ZEVALIN. All results were within US Nuclear Regulatory Commission conformance limits (+/-20%) for defining therapeutic misadministrations.


Subject(s)
Antibodies, Monoclonal/analysis , Radiopharmaceuticals/analysis , Yttrium Radioisotopes/analysis , Ambulatory Care Facilities/standards , Antibodies, Monoclonal/therapeutic use , Humans , Neoplasms/radiotherapy , Nuclear Medicine/standards , Pharmacies/standards , Pilot Projects , Quality Control , Radioimmunotherapy , Radiometry/methods , Radiometry/standards , Radiopharmaceuticals/standards , Radiopharmaceuticals/therapeutic use , Radiotherapy Dosage , Reference Standards , United States , Yttrium Radioisotopes/standards , Yttrium Radioisotopes/therapeutic use
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