Subject(s)
Metronidazole/administration & dosage , Radiation-Sensitizing Agents/administration & dosage , Uterine Cervical Neoplasms/radiotherapy , Administration, Topical , Clinical Trials as Topic , Combined Modality Therapy , Female , Humans , Metronidazole/therapeutic use , Middle Aged , Radiotherapy Dosage , Uterine Cervical Neoplasms/drug therapy , Uterine Cervical Neoplasms/mortalityABSTRACT
In a recently started clinical trial, the short-term effects of radiotherapy of cervix cancer Stage IIb and III in combination with topical infusion of metronidazole solution were evaluated by determining the local clearance rate and cytologic damage in randomized and non-randomized cases. In regard to the short term effects the combined treatment was found to be superior to treatment without metronidazole.
Subject(s)
Metronidazole/therapeutic use , Uterine Cervical Neoplasms/radiotherapy , Clinical Trials as Topic , Combined Modality Therapy , Female , Humans , Metronidazole/administration & dosage , Random AllocationSubject(s)
Lung Neoplasms/therapy , Preoperative Care , Bulgaria , Combined Modality Therapy , Czechoslovakia , Female , Humans , Hungary , Lung Neoplasms/mortality , Male , Middle Aged , Multicenter Studies as Topic , Pneumonectomy , Poland , Radiotherapy Dosage , Time Factors , USSRABSTRACT
The results of a cooperative study on combined treatment and preoperative radiotherapy in 478 lung cancer patients were analyzed. Intensive fractionated radiotherapy was given at doses of 4 Gy for 5 days, the total dosage thus attaining 20 Gy. 218 patients received combined treatment, 260 patients were treated only surgically. A comparison of the 5-year survival rates of Stage I and II patients did not show any advantage in favor of the used therapeutic modality. The combined treatment with preoperative radiotherapy, however, improved the survival rates of Stage III patients with non-small cell lung cancer. The 3-year rate in these patients was 49.4% and the 5-year rate was 29.2%, while those found in the patients treated only surgically were 28.1% and 15.8%, respectively. In all patients with regional metastases the effectiveness of the treatment was higher when the combined method was employed.
