1.
Biochem Biophys Res Commun
; 143(2): 732-9, 1987 Mar 13.
Article
in English
| MEDLINE
| ID: mdl-3551955
ABSTRACT
Three drug-resistant sublines of the murine macrophage-like cell line J774.2 were selected in vitro for their ability to grow in high concentrations of either taxol, vinblastine, or colchicine. Each contains a major plasma membrane glycoprotein (130-150 kDa), which is barely seen in the drug-sensitive parental cell line. Polyclonal antibodies, raised against the glycoproteins present in the colchicine- and vinblastine-resistant cells, were used to probe for relationships among the three glycoproteins. Our observations suggest that the glycoproteins from the different drug-resistant cell lines share many common domains but are not identical.
Subject(s)
Drug Resistance , Glycoproteins/immunology , Membrane Proteins/immunology , Animals , Antibody Specificity , Cell Line , Cell Membrane/immunology , Fluorescent Antibody Technique , Macrophages , Mice , Molecular Weight , Peptide Fragments/analysis
2.
Cancer Res
; 37(7 Pt 1): 2226-31, 1977 Jul.
Article
in English
| MEDLINE
| ID: mdl-861948