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Purification of p-nitrobenzyl C-functionalized diethylenetriamine pentaacetic acids for clinical applications using anion-exchange chromatography.
Brechbiel, M W; Beitzel, P M; Gansow, O A.
J Chromatogr A ; 771(1-2): 63-9, 1997 May 30.
Article in English | MEDLINE | ID: mdl-9210313

ABSTRACT

A general process for the purification of large quantities (5-10 g) of p-nitrobenzyl C-functionalized diethylenetriamine pentaacetic acids is reported. The method of choice to achieve purification for clinical applications is anion-exchange chromatography.


Subject(s)
Chromatography, Ion Exchange/methods , Pentetic Acid/isolation & purification , Chromatography, High Pressure Liquid/instrumentation , Chromatography, High Pressure Liquid/methods , Chromatography, Ion Exchange/instrumentation , Magnetic Resonance Spectroscopy , Pentetic Acid/chemistry
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