ABSTRACT
A study of 63 patients with uncomplicated forms of ulcer of the duodenum revealed an increased aggregation activity of erythrocytes, reduction of their capacity to deformation, abnormal stability to oxygen hemolysis, increase of lipid peroxidation in erythrocytes. These disorders of the functional state of erythrocytes depended on the character of complication of the ulcer disease and are related to activation of the processes of lipid peroxidation. Antioxidant drugs are indicated.
Subject(s)
Duodenal Ulcer/complications , Erythrocytes/physiology , Peptic Ulcer Hemorrhage/blood , Peptic Ulcer Perforation/blood , Pyloric Stenosis/blood , Adult , Chronic Disease , Duodenal Ulcer/blood , Female , Humans , Lipid Peroxidation/physiology , Male , Middle AgedABSTRACT
Free-radical lipid oxidation (FRLO), antioxidant system and rheological blood properties were studied in 63 patients with ulcer disease, of them, in 39--complicated by acute bleeding. Twenty healthy subjects served as a control. It was established, that hemorrhage led to considerable FRLO activation. The correlation between the increase in the content of the FRLO products in the erythrocytes and their functional properties was revealed.
