[Mechanisms of action of NAD in cerebral circulatory insufficiency]. / Mekhanizmy deistviia NAD pri nedostatochnosti krovosnabzheniia mozga.

Nicotinamide adenine dinucleotide (NAD) decreases the resistance of cerebral vessels and increases the local (hydrogen clearance) and regional (133Xe clearance) cortical blood flow in intact cats. In cerebral blood flow deficiency the level of ammonia in brain tissue is appreciably increased. Favouring normalization of the deranged cerebral blood flow NAD neutralizes excess ammonia by means of glutamate dehydrogenase activity recovery in the reduction amination reaction. This indicates that NAD influences the neurochemical mechanisms of compensatory regulation of the cerebral blood flow.

[Neurochemical mechanisms of the effect of euphylline in cerebral blood flow deficiency]. / Neirokhimicheskie mekhanizmy deistviia eufillina pri defitsite mozgovogo krovotoka.

In cerebral blood flow deficiency the level of ammonia in the cerebral tissue is appreciably increased and the activity of glutamate dehydrogenase (GDH) is decreased without material variations in the content of glutamine and amide groups of protein. Favouring normalization of the deranged cerebral blood flow, euphylline neutralizes excess ammonia by means of GDH activity recovery in the reduction amination reaction. The drug exhibited the most pronounced effect during acute cerebral ischemia. This indicates that euphylline influences the neurochemical mechanisms of the compensatory regulation of cerebral blood flow.