[Secondary splenomegaly in cholestasis and disorders of portal blood flow in an experiment detectable by intravenous liposome splenography]. / Vtorichnaia splenomegaliia pri kholestaze i narusheniiakh portal'nogo krovotoka v éksperimente, vyiavliaemaia s pomoshch'iu vnutrivennoi liposomnoi lienografii.

The paper is concerned with the results showing high diagnostic potentialities of i.v. liposome lienography for the detection of the splenomegalic syndrome in acute cholestasis, cholestatic hepatitis and disturbances of the extrahepatic portal blood flow. The authors managed to establish the dependence of the value of secondary splenomegaly on the period of cholestasis and a degree of occlusion of the portal vein. In acute cholestasis splenomegaly was manifested in 5 days by a two-fold increase in the spleen with reverse development within 2.5 mos. A rapid 2-fold increase in the spleen for 24 h was noted in occlusion of the portal vein by 40%, and a three-fold increase was noted in 5 mos. with subsequent death of the animals. A decrease in the extrahepatic portal blood flow by 25% also resulted in splenomegaly but without death of the animals. The authors have assumed that the use of i.v. liposome lienography ensures timely diagnosis of the splenomegalic syndrome and provides an opportunity to assess function of the reticuloendothelial system of the spleen.

[Roentgenocontrast lienography in experimental diffuse liver lesions]. / Rentgenokontrastnaia lienografiia pri éksperimental'nom diffuznom porazhenii pecheni.

The diagnostic potentialities of i. v. lienography were studied in experiments on rodents during the administration of the liposome forms of radiographic contrast agents (RCA) in the presence of chronic diffuse liver lesion simulated by subcutaneous injection of 50% oil solution of CCl4 for 2 months. The time-course of splenomegaly was found to be in direct relation to the CCl4 summary dose. The degree of pathomorphological changes of the hepatic tissue and pathological shifts in the blood clinical and biochemical findings show good correlation with the time-course of splenomegaly. The use of the RCA liposome forms extends the range of radiodiagnostic potentialities in the recognition of chronic diffuse liver lesion.