[A case of seronegative systemic lupus erythematosus (an immunopathological study)]. / Sluchai seronegativnoi sistemnoi krasnoi volchanki (immunopatologicheskoe issledovanie).

A case of systemic lupus erythematosus (SLE) in a 37-year-old female is described which was primarily diagnosed as epilepsy. Immunopathologically, an immunoglobulin in the nuclei of the majority of cells in the skin biopsy and blood cells was found against the background of the lack of SLE manifestations (antinuclear factor in the circulating blood, skin lesions, etc.). Antibodies against the antigen of vascular intima are revealed in the blood by means of the indirect immunofluorescence. The epilepsy diagnosis was established due to the prevalence of the brain vessels affection (frequent loss of consciousness). The progression of the disease with the involvement of joints, heart, lungs and other organs, high indexes of the rheumatoid factor made it necessary to differentiate between rheumatoid arthritis and SLE. The immunopathological examination confirmed the SLE diagnosis. Hemosorption combined with a standard therapy was followed by the decrease of the immunopathological manifestations.

[Purification of biological fluids by sorbents on a base of industrial activated charcoal]. / Ochistka biologicneskikh zhidkostei sorbentami na osnove promyshlennykh aktivnykh uglei.

The authors propose using industrial activated carbon as a base for hemosorbents and show the methods of choosing the optimal size of the sorbent grain. The results of using the column with a pseudo-liquefied layer and the apparatus with an unfixed layer of hemosorbent are given. Using enterosorption was proposed for the treatment of a number of disorders including allergic diseases.

[Effect of hemosorption on the dynamics of immunopathologic changes in the skin of patients with diseases accompanying the immune complex syndrome]. / Vliianie gemosorpbtsi na dinamiku immunopatologicheskkh izmenenii v kozhe bol'nykh s zabolevaniiami, soprovozhdaiushchimisia sindromom immunnykh kompleksov.

In the majority of diseases with the immune complexes (IC) syndrome, elimination of IC from the body is markedly disturbed. The authors carried out a study with the aid of the direct immunofluorsecence technique. The use of hemosorption in the treatment of patients with grave patterns of systemic lupus erythematosus, rheumatoid arthritis, psoriasis, systemic vasculitis and similar illnesses in conjunction with conventional therapy (corticosteroids, cytostatics) leads to sequestration of the depositions of immune complexes from the skin. As early as after the first hemosorption one can observe the displacement of IC from the derma to the epidermis, advance of IC towards the stratum corneum. After the third session in hemosorption IC granules appear on the body surface, in the form of warty formulations which are removed afterwards together with skin scales. It is assumed that hemosorption recovers the secretory function of the skin, aimed at IC elimination.