Subject(s)
Heart Block/chemically induced , Pentoxifylline/adverse effects , Phosphodiesterase Inhibitors/adverse effects , Vasodilator Agents/adverse effects , Aged , Angina Pectoris/drug therapy , Female , Humans , Injections, Intravenous , Pentoxifylline/administration & dosage , Phosphodiesterase Inhibitors/administration & dosage , Vasodilator Agents/administration & dosageABSTRACT
The effect of riboxin (100 mg/kg body weight) on different kinds of metabolism in the cardiac muscles of Wistar rats in norm and during experimental pituitrin-neoepinephrine-induced myocardial infarction was studied. Riboxin was found to stimulate anaerobic glycolysis with the hyperproduction of lactate and the formation of glucose deficiency and also to increase the rate of protein synthesis on polyribosomes. Administration of riboxin during the formation of myocardial infarction considerably hinders the pronounced character of its electrocardiographic and biochemical manifestations. Thus, in the ischemic cardiac muscle the pool of macroergic phosphates is preserved, glycolysis and adaptive protein synthesis are impaired to a lesser degree that probably underlies the cardioprotective effect of riboxin.
Subject(s)
Inosine Diphosphate/pharmacology , Inosine Nucleotides/pharmacology , Animals , Drug Evaluation, Preclinical , Energy Metabolism/drug effects , Female , Heart/drug effects , Inosine Diphosphate/therapeutic use , Isoproterenol , Male , Myocardial Infarction/chemically induced , Myocardial Infarction/drug therapy , Myocardial Infarction/metabolism , Myocardium/metabolism , Pituitary Hormones, Posterior , Rats , Rats, Inbred StrainsABSTRACT
The effect of malic acid salts of iron, potassium, copper, chromium, lithium and zinc on the motor activity and electroencephalographic indices in rats was studied under the course of oral treatment (250 mg/kg). Potassium malate was found to exert the most pronounced stimulating effect on the motor activity and excitatory processes in the sensory motor brain areas. The study of the influence of this compound on total physical working capacity and its restoration revealed a significant dose-dependent stimulating action. It was shown that the effects of potassium malate are related to its ability to stimulate the most productive bioenergetic processes, to increase carbohydrate reserves, to decrease oxygen consumption of tissues.