ABSTRACT
Sulpiride (120 mg/kg, i.p.) inhibited saline-induced diuresis in the rat, an effect not observed with haloperidol, clozapine, pimozide or chloromazine. The antidiuretic effect of sulpiride also occurred in hypophysectomized rats suggesting that the response was not prolactin-mediated.
Subject(s)
Diuresis/drug effects , Sodium Chloride/antagonists & inhibitors , Sulpiride/pharmacology , Animals , Antipsychotic Agents/pharmacology , Female , Hypophysectomy , RatsABSTRACT
Experiments were conducted to determine the effect of ingested polyethyleneimine upon gastric emptying of the fasted rat. Emptying was evaluated by the phenolsulfonphthalein and resin bead methods. The two techniques gave comparable results; both showed that this agent inhibited gastric emptying. A delay in gastric emptying could be detected within 15 min of intubation. The effect was dose related, quite long lasting (approximately 4 hr), and reversible. Commercially available, branched polyethyleneimines were highly active, but the linear polyethyleneimine was without observable effect. A branched polyethyleneimine derivative with all primary amine sites selectively acetylated also was inactive.
Subject(s)
Gastrointestinal Motility/drug effects , Polyethyleneimine/pharmacology , Polyethylenes/pharmacology , Animals , Depression, Chemical , Female , Microspheres , Molecular Weight , Phenolsulfonphthalein , Rats , Time FactorsSubject(s)
Blood Coagulation/drug effects , Diuretics/pharmacology , Heparin/pharmacology , Protamines/pharmacology , Quinazolines/pharmacology , Sulfonamides , Animals , Chlorides/urine , Diuresis/drug effects , Dogs , Drug Interactions , Heparin Antagonists , Natriuresis/drug effects , Time FactorsABSTRACT
1. Metolazone, a new diuretic, was found to be excreted by glomerular filtration and renal tubular secretion.2. The secretory mechanism was antagonized by probenecid but this did not affect the diuretic action of metolazone.
