ABSTRACT
The aim of the work was to study the role of atorvastatin in the correction of oxidative stress manifestations in patients with coronary heart disease and dyslipidemnia (DLP). It included 122 patients with stable forms of CHD and 20 practically healthy subjects. Plasma lipids and products of lipid peroxidation (dienic conjugates and compounds reacting with 2-thiobarbituric acid), eryhrocyte antioxidative enzymes glutathione peroxidase and superoxide dismutase were determined by standard methods; activity of the ceruloplasmin/transferrin antioxidant system) was measured by electron paramagnetic resonance. The patients underwent 24 hr ECG Holter monitoring. Atorvastatin at a dose of 20 mg/d given during 6 months exerted antioxidative and antiperoxidative effects in 90% of the patients. It normalized parameters of lipid peroxidation and antioxidant protection thereby improving the clinical course of CHD.
Subject(s)
Coronary Disease/drug therapy , Heptanoic Acids/pharmacology , Obesity/complications , Oxidative Stress/drug effects , Pyrroles/pharmacology , Adult , Aged , Antioxidants/metabolism , Antioxidants/pharmacology , Antioxidants/therapeutic use , Atorvastatin , Case-Control Studies , Coronary Disease/physiopathology , Dyslipidemias/drug therapy , Dyslipidemias/physiopathology , Electrocardiography, Ambulatory , Electron Spin Resonance Spectroscopy , Female , Heptanoic Acids/therapeutic use , Humans , Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology , Lipid Peroxidation/drug effects , Lipids/blood , Middle Aged , Pyrroles/therapeutic useSubject(s)
Hypoxia/metabolism , Myocardium/metabolism , Nitric Oxide/biosynthesis , Animals , Electron Spin Resonance Spectroscopy/methods , Heart/drug effects , Male , Nitric Oxide Synthase/antagonists & inhibitors , Nitroarginine/administration & dosage , Rats , Sodium Nitrite/administration & dosageABSTRACT
In experiments on mice we studied the effect of individual or combined treatment with mexidol and nitroglycerine on iron-sulfur centers of the mitochondrial respiratory chain, cytochrome P-450 of the endoplasmic reticulum, and nitric oxide formation in the liver tissue. Mexidol had a potent effect on these parameters and protected iron-sulfur centers from oxidation, including that induced by nitroglycerine.
