ABSTRACT
Presentamos el caso de un paciente con enfermedad de Crohnde larga evolución y con múltiples complicaciones de su enfermedadque, tras recibir tratamiento con infliximab, es diagnosticadode un adenocarcinoma de recto y ano que precisa cirugía radical,presentando posteriormente metástasis múltiples. Se repasarándurante la discusión las características y los factores de riesgo másimportantes del cáncer colorrectal en pacientes con enfermedadinflamatoria intestinal, y se analizarán los trabajos existentes hastala fecha en relación con la aparición de neoplasias en pacientestratados con fármacos biológicos(AU)
In the present paper, we report the case of a patient with longstandingCrohns disease and multiple complications that, after receivingtreatment with infliximab, was diagnosed with an adenocarcinomaof the rectum and anus that required radical surgery,later presenting multiple metastases. In the discussion, characteristicsand major risk factors for colorectal cancer in patients withinflammatory bowel disease will be largely reviewed, and currentstudies will be analyzed in connection with the appearance of neoplasmsin patients being treated with biologics(AU)
Subject(s)
Humans , Male , Middle Aged , Adenocarcinoma/complications , Adenocarcinoma/diagnosis , Crohn Disease/complications , Rectal Neoplasms/complications , Anus Neoplasms/complications , Antibodies, Monoclonal/therapeutic use , Colonoscopy , Mesalamine/therapeutic use , Ileal Diseases/physiopathology , Colostomy/methods , Adenocarcinoma/physiopathology , Ileal Diseases , Crohn Disease/drug therapy , Adenocarcinoma , Rectal Neoplasms , Rectum/pathology , Rectum , Anastomosis, Surgical , Early DiagnosisABSTRACT
In the present paper, we report the case of a patient with long-standing Crohn s disease and multiple complications that, after receiving treatment with infliximab, was diagnosed with an adenocarcinoma of the rectum and anus that required radical surgery, later presenting multiple metastases. In the discussion, characteristics and major risk factors for colorectal cancer in patients with inflammatory bowel disease will be largely reviewed, and current studies will be analyzed in connection with the appearance of neoplasms in patients being treated with biologics.
Subject(s)
Adenocarcinoma/chemically induced , Antibodies, Monoclonal/adverse effects , Anus Neoplasms/chemically induced , Crohn Disease/drug therapy , Rectal Neoplasms/chemically induced , Tumor Necrosis Factor-alpha/antagonists & inhibitors , Antibodies, Monoclonal/therapeutic use , Humans , Infliximab , Male , Middle AgedABSTRACT
No disponible
Subject(s)
Humans , Female , Middle Aged , Pancreatitis/complications , Pancreatitis/diagnosis , Hypercalcemia/complications , Hypercalcemia/diagnosis , Hypercalcemia , Abdominal Pain/complications , Radiography, ThoracicABSTRACT
Hypercalcemia due to hyperparathyroidism is a rare etiology for acute pancreatitis, oscillating between 1.5 and 7% in the different series. Although the cause-effect relationship and the pathophysiology of the condition are not clear, it seems that the association among them is not incidental, and serum calcium could be a major risk factor, so that pancreatitis would come to occur during severe hypercalcemia attacks. Mutations in different genes have been proposed as well to justify why only some patients with primary hyperparathyroidism and hypercalcemia develop acute pancreatitis. References to cases like these ones are rare in the literature. We report two patients with acute pancreatitis associated with hyperparathyroidism and hypercalcemia, one of them with a fatal outcome.
Subject(s)
Hypercalcemia/complications , Hyperparathyroidism/complications , Pancreatitis/etiology , Acute Disease , Aged , Humans , Male , Middle AgedABSTRACT
La hipercalcemia secundaria a hiperparatiroidismo es una causarara de pancreatitis aguda, variando entre el 1,5-7% según lasseries consultadas. Aunque la relación causal y la fisiopatología delproceso no están totalmente aclaradas, parece claro que la asociaciónno es incidental y que los niveles de calcio sérico serían unfactor de riesgo mayor, desencadenándose los cuadros de pancreatitisdurante las crisis de hipercalcemia. También se han descritoalteraciones en diversos genes que podrían estar implicados,justificando por qué sólo unos pocos pacientes con hiperparatiroidismoprimario e hipercalcemia sufren pancreatitis aguda.Existen muy pocas referencias en la literatura a casos como losque nos ocupan. Presentamos a continuación dos pacientes concuadros de pancreatitis aguda asociados a hiperparatiroidismo ehipercalcemia, uno de ellos con desenlace fatal(AU)
Hypercalcemia due to hyperparathyroidism is a rare etiology for acute pancreatitis, oscillating between 1.5 and 7% in the different series. Although the cause-effect relationship and the pathophysiology of the condition are not clear, it seems that the association among them is not incidental, and serum calcium could be a major risk factor, so that pancreatitis would come to occur during severe hypercalcemia attacks. Mutations in different genes have been proposed as well to justify why only some patients with primary hyperparathyroidism and hypercalcemia develop acute pancreatitis. References to cases like these ones are rare in the literature. We report two patients with acute pancreatitis associated with hyperparathyroidism and hypercalcemia, one of them with a fatal outcome(AU)
