ABSTRACT
Enzymatic and nonenzymatic components of the antioxidant system were studied in the erythrocytes, saliva and gastric juice of 20 healthy volunteers, 113 children with chronic gastroduodenitis and duodenal ulcerous disease. A decrease in the activity of superoxide dismutase and imbalance of the glutathione redox system were found both in the erythrocytes and the digestive secrets of children with gastroduodenal pathology. The rate of impairments depended on the gastric functional state, on the nature of disease development; the most pronounced alterations were detected in the gastric juice.
Subject(s)
Antioxidants/metabolism , Duodenal Ulcer/metabolism , Erythrocytes/metabolism , Gastric Juice/metabolism , Gastritis/metabolism , Saliva/metabolism , Adolescent , Child , Child, Preschool , Glutathione/metabolism , Humans , Superoxide Dismutase/metabolismABSTRACT
A decrease in the superoxide anion-obviating activity of gastric juice was detected in patients with chronic gastroduodenitis and duodenal ulcerous disease, whose rate depended on the disease stage, functional state of the stomach and nature of the disease course. Deficiency in H+, Cu2+ and a decrease of glutathione content in gastric juice were found to be responsible for the phenomenon observed. The superoxide anion-obviating activity of gastric juice exhibited the regulatory effect on resistance of the duodenal mucosal membrane, which is prerequisite to restoration of the pattern studied during medicinal treatment. Antacid biphilact produced from sour milk was used for the treatment of the disease.
Subject(s)
Duodenal Ulcer/metabolism , Gastric Juice/metabolism , Gastroenteritis/metabolism , Superoxides/metabolism , Adolescent , Child , Child, Preschool , Copper/metabolism , Gastric Juice/chemistry , Glutathione/metabolism , Humans , Hydrogen/metabolism , Infant , Iron/metabolismABSTRACT
Individual regimens of acupuncture were applied in treatment of 66 children with various gastrointestinal diseases. As a result, the effect of the combined treatment rose 1.4-fold.