[Interactions of sulfanilamides, penicillins and acetylsalicylic acid in serum protein binding]. / Vzaimodeistvie sul'fanilamidov, penitsillinov i atsetilsalitsilovoi kisloty pri sviazyvanii ikh syvorotochnymi belkami.

Combined use of sulfalen and sulfadimethoxine with benzylpenicillin and ampicillin resulted in increased binding of sulfalen to serum proteins of man. Acetylsalicylic acid promoted a decrease in the sulfanilamide binding to the serum proteins. The observed changes in the sulfanilamide binding to proteins of human blood serum were due to increased or decreased affinity of the drugs to the protein molecules.

[Distribution of sulfanilamides and penicillins in the blood and organs of rats after their combined administration]. / Raspredelenie sul'fanilamidov i penicillinov v krovi i organakh krys pri kombinirovannom primenenii lekarstv.

The use of benzylpenicillin and ampicillin in combination with sulfalen or sulfadimethoxine increased the levels of the penicillins and sulfalen in some organs and tissues of rats. This was accompanied by a rise in the concentration gradients of the drugs. It is concluded that the combined use of the penicillins and sulfanilamides determines their increased penetration from the blood into other organs and tissues of the host.

[Pharmacodynamics of cephaloridine and cephalothin combined with sulfalene in rabbits]. / Farmakokinetika tsefaloridina i tsefalotina u krolikov pri kombinirovannom primenenii s sul'falenom.

The combined use of cephaloridin and cephalothin with sulfalen resulted in decreased binding of the cephalosporins by serum proteins and decreased rate of drug elimination in rabbits. It might be suggested that these two processes were interrelated. The decreased binding of the antibiotics by proteins in rabbits promoted an increase in the volume distribution of the drugs at the expense of a rise in the level of their penetration from the blood into the peripheral tissues.

[Effect of acetylsalicylic acid on sulfalene and sulfadimethoxine binding by serum proteins and on their kinetics in rabbits]. / O vliianii atsetilsalitsilovoi kisloty na sviazyvanie sul'falena i sul'fadimetoksina syvorotochnymi belkami i na ikh kinetiku u krolikov.

The use of sulfalen and sulfadimethoxine in combination with acetylsalicylic acid resulted in the decreased binding of the sulfanilamides by serum proteins, most pronounced with respect to sulfadimethoxine. The decreased binding of the drugs by serum proteins in rabbits was accompanied by decreased elimination of sulfalen and increased excretion of sulfadimethoxine from the host. The different effect of acetylsalicylic acid on the kinetics of sulfalen and sulfadimethoxine in the rabbits was partially due to the unequivalent effect of the decreased binding of the sulfanilamides by the serum proteins on their combined use.

[Sulfadimethoxine pharmacokinetics in mechanical jaundice and cholangitis]. / Farmakokinetika sul'fadimetoksina u bol'nykh mekhanicheskoi zheltukhoi i kholangitom.

The rate of sulfadimethoxine excretion from blood in patients with mechanical jaundice and cholangitis is the same as that in healthy persons. The renal excretion of the drug in such patients does not undergo any significant changes either. However, excretion of sulfadimethoxine with bile is impaired and the level of suppression of renal excretory function is proportional to the jaundice period. After decompression of the bile ducts renal excretory function in patients with mechanical jaundice is recovered.