Dalfampridine as a promising agent in the management of hereditary spastic paraplegia: A triple-blinded, randomized, placebo-controlled pilot trial.

Limited but encouraging results support the use of dalfampridine in patients with hereditary spastic paraplegia (HSP). Our aim was to investigate the effects of dalfampridine on walking speed, muscle length, spasticity, functional strength, and functional mobility in patients with HSP. In this triple-blinded, randomized, placebo-controlled pilot trial, four patients with HSP received dalfampridine (10 mg twice daily) in addition to physiotherapy (twice a week), and four patients received placebo in addition to physiotherapy for eight weeks. The group allocation was masked from the assessor, treating physiotherapists, and patients. The primary outcome was the Timed 25-foot Walk Test (T25FWT) at the end of the eight-week treatment. The secondary outcome measures were functional mobility, functional muscle strength, muscle length, and spasticity. The improvement in the T25FWT values was significantly higher in the experimental group than in the control group (p < 0.05). All patients in the experimental group exceeded the proposed minimally important clinical difference for T25FWT. The degrees of improvement in most muscle length and spasticity assessments and functional muscle strength were also higher in the experimental group (p < 0.05). No significant difference was observed between the groups regarding functional mobility (p > 0.05). No adverse events or side effects were noted. This pilot trial yields encouraging evidence that the combination of dalfampridine and physiotherapy may enhance muscle parameters and improve walking speed in patients with HSP. However, further research involving larger sample sizes and more comprehensive assessments is needed to validate these results and establish the clinical benefits of this treatment approach. Trial registration ID: NCT05613114 (https://clinicaltrials.gov/), retrospectively registered on November 14, 2022.

Pain coping strategies and related factors including demographics, pain characteristics, functional mobility in postmenopausal women with chronic musculoskeletal pain.

This cross-sectional study investigated pain coping strategies and their relationship to demographic and clinical characteristics in postmenopausal women (PMWs) with chronic musculoskeletal pain (CMSP). PmW (n = 60) who presented to receive physiotherapy from a rehabilitation center participated. McGill Pain Questionnaire (MPQ) was used to assess pain intensity and characteristics, Pain Coping Inventory (PCI) was used to assess strategies of coping with pain, and Timed Up and Go-Test (TUG) was used to assess functional mobility. Data were analyzed using descriptive analyses, paired-samples t-test, independent-samples t-test, Mann Whitney U-test, one-way ANOVA, and Pearson's correlation analysis. There was no significant difference in terms of marital status, educational status, and exercise habits between the participants' statuses of using active and passive strategies of coping with pain. Younger women (50-59 years of age) preferred active strategies more than passive strategies to cope with pain (p = .047). There were significant differences among the age groups in terms of "pain transformation" subdomain of active strategies (p = .007) and "sensory" subdomain of MPQ (p = .053). Strategies of coping with pain and functional mobility of participants were not significantly related (p > .05). Results indicated that age is a significant factor in coping with pain and pain characteristics. Healthcare providers should consider PmW's preferences and experiences with pain management when recommending pain management strategies.

Analysis of physical activity level and body awareness of mothers of children with special needs.

We aimed to analyze physical activity level and body awareness of mothers of children with physical disability and to compare with mothers without a disabled child. A total of 102 participants including 51 mothers with a disabled child and 51 mothers without a disabled child were included (average age 38.59 ± 5.98). Body Awareness Questionnaire (BAQ) and International Physical Activity Questionnaire-Short Form (IPAQ-SF) were used as data collection tools. It was found that physical activity levels and body awareness of the mothers with a disabled child were lower than mothers without a disabled child. In conclusion, during rehabilitation of children with physical disability, mothers should become a part of the treatment, their participation in physical activity programs and body awareness training should be encouraged.

Effect of clinical Pilates training on balance and postural control in patients with Parkinson's disease: a randomized controlled trial.

Background: Clinical pilates exercises have been shown to improve balance. Our study aims to compare effects of clinical Pilates and conventional physiotherapy exercises on balance and postural control in Parkinson's disease patients. Materials & methods: Forty patients were randomly assigned into either clinical Pilates (CLP) or conventional physiotherapy (COP) group. Exercises were performed twice a week for 8 weeks. Balance, lower-extremity strength, fall risk and functional mobility were assessed at the beginning and end of the exercise period. Results: All measurements indicated significant increase in two groups (p < 0.05). Compared with the COP group, the CLP group showed significant improvement in dynamic balance values (p < 0.05). Conclusion: CLP was as effective as COP, with better dynamic balance results, and could be used in rehabilitation for patients with Parkinson's disease. Clinical trial registration number: NCT04063605.

The effect of pain severity on balance, postural stability and fall risk in patients with shoulder pathologies.

INTRODUCTION: The study aimed to investigate how pain severity in the shoulder region affects balance ability, postural stability and fall risk. MATERIAL AND METHODS: Sixty participants with shoulder pain, aged 42.45 ±6.51 years, were assessed using a Visual Analog Scale (VAS); they were divided into 2 subgroups as a mild pain group (group 1) and a moderate/severe pain group (group 2). According to VAS-at rest the mild-pain group included 39 and the moderate/severe-pain group included 21 subjects. According to VAS-during movement, the mild-pain group included 19 and the moderate/severe-pain group included 41 subjects. Balance ability-postural stability, fall risk and fear of falling were assessed by the Sportkat System, Berg Balance Scale (BBS), and Fall Efficacy scale (FES) respectively. Differences of variables between mild pain and moderate/severe pain groups were analyzed by the independent groups t-test in groups conforming to a normal distribution and the Mann-Whitney U test for the variables that did not fit a normal distribution. RESULTS: A positive relationship was found between VAS-at rest and double-foot static balance test score right-left (RL) ratio, while a negative relationship was found between VAS-at rest and BBS score (p < 0.05). Significant differences were found between right foot static balance left score and RL ratio according to pain at rest (p < 0.05). CONCLUSIONS: The results indicated that shoulder pain severity affects balance parameters. As pain level at rest increases, postural sway increases in a medio-lateral direction, and towards the left while standing on the right foot. Approaches regarding increasing balance and postural instability should be included in physiotherapy and rehabilitation programs of patients with shoulder pain at an early phase to protect patients from balance problems and fall risk.

The effect of clinical pilates-based physiotherapy program for a Stiff Person Syndrome patient: a case report.

The aim of the present report is to show the effects of a clinical pilates-based physiotherapy training program on physical functioning, including balance ability, flexibility, muscle strength, and pain severity in a case with Stiff Person Syndrome (SPS). A 43-year-old female with a 3-year history of SPS participated in the study. Clinical pilates training exercises were performed two times per week during 8 weeks. Static balance was evaluated with One Leg Stance Test and Tandem Stance Test, dynamic balance with Functional Reach Test and lower extremity strength and endurance measured by 30-s Chair Stand Test. Berg Balance Scale was used to assess balance and fall risk, and Timed Up and Go Test was used to assess functional mobility. Pain evaluation was done by Pain Quality Assessment Scale. Flexibility was measured with tape measure, range of motion with goniometer and muscle strength with manual muscle test. Among the balance and functional mobility tests, progress has been observed in all tests, except for 30-s Chair Stand test. Improvements have been observed in patient's range of motion, flexibility, strength, pain and balance parameters. Clinical pilates-based physiotherapy program had positive effects on many physical and functional parameters of the patient and can be used as a safe exercise method in physiotherapy rehabilitation of SPS.

Determination of exercise habits, physical activity level and anxiety level of postmenopausal women during COVID-19 pandemic.

In this study, researchers aimed to determine exercise habits, physical activity (PA) levels and anxiety levels of postmenopausal women (PMw) during the self-quarantine period of the COVID-19 pandemic. 104 PMw (59.00 ± 6.61 years old) participated in the study. It was found that PMw who had exercise habits before the pandemic period had higher PA levels, and the women with high anxiety levels during the pandemic had lower PA levels (p < .05). Anxiety levels and PA were negatively associated with each other. Numbers of grandchildren also affected the PA and anxiety levels of the PMw negatively. Women should be encouraged to initiate or maintain PA levels in all circumstances.