ABSTRACT
The probability to develop lung cancer before 80 years of age is 1.67 and 0.18% for the male and female populations of Kharkov, respectively; the probability to develop large-intestine cancer is 0.92 and 0.49%, respectively. The correlation coefficient (r) of the age of manifestation (AM) of cancer in parent-offspring pairs is 0.47. These correlation coefficients for the father-son, mother-daughter, mother-son, and father-daughter pairs are 0.64, 0.49, 0.44, and 0.37, respectively. If the parent has lung cancer, the correlation is stronger (r = 0.71). On average, cancer is manifested in offspring earlier than in parents (57 and 63 years, respectively); the differences in the father-daughter and mother-son pairs are 8.2 and 2.8 years, respectively. The best prognostic parameter is the AM of cancer in the father with respect to the AM in the son (byx = 0.45).
Subject(s)
Colonic Neoplasms/genetics , Genetic Predisposition to Disease , Lung Neoplasms/genetics , Adolescent , Adult , Aged , Aged, 80 and over , Child , Child, Preschool , Humans , Infant , Infant, Newborn , Middle AgedABSTRACT
A simple and sensitive method is developed to determine the glutaminase activity. Conditions are selected for detecting enzymatically formed ammonia in the presence of such a high-labile substrate as glutamine. The method is simple in performance, readily reproducible and high-sensitive.
