ABSTRACT
The article extensively covers the historical stages of the development of enteral oxygenation technique. There is shown the long way of scientific research from the first using of "oxygenating" products in the early XX century to undertaken hundred years after attempts of the oxygen introduction into gastrointestinal tract for systemic oxygenation improvement and prevention of intestinal flora translocation in sepsis. On the basis of anatomical and physiological characteristics of the intestinal wall there was shown the possibility of both local and systemic effects of the oxygen introduced into the intestinal tract. The hypothesis about the possibility of improving homeostasis and pulmonary gas exchange by normalizing the functioning of the gastrointestinal tract was presented.
Subject(s)
Gastrointestinal Tract , Insufflation/methods , Oxygen/administration & dosage , Oxygen/therapeutic use , Gastrointestinal Tract/anatomy & histology , Gastrointestinal Tract/blood supply , Gastrointestinal Tract/physiology , History, 19th Century , History, 20th Century , History, 21st Century , Humans , Insufflation/history , Microcirculation/drug effects , Oxygen Consumption/physiologyABSTRACT
OBJECTIVE: To study possibilities of enteral oxygen therapy for the improvement of systemic oxygenation. We studied 34 critical patients. RESULTS: Insufflation of oxygen into intestines brought to delayed and prolonged increase of systemic oxygenation (PaO2 and PaO2/FiO2 growth, p<0.001, ANOVA, Holm-Sidack test) reaching its maximum in 9 hours after the insufflation procedure and lasting 32 hrs. Oxygen administration into stomach did not result to better oxygenation. CONCLUSIONS: Taking into account low volumes of insufflated oxygen (from 2 to 6 L) and the duration of achieved systemic oxygenating effect, we may suggest that mechanism of systemic oxygenation was not based on the direct intestinal oxygen absorption, but rather due to normalization of the gastrointestinal tract functions and followed systemic metabolism change improving pulmonary gas exchange. Future investigations are needed to clarify mechanisms.
Subject(s)
Insufflation/methods , Oxygen Consumption/drug effects , Oxygen Inhalation Therapy/methods , Oxygen , Absorption, Physiological , Female , Gastric Mucosa/metabolism , Hemodynamics/drug effects , Humans , Insufflation/instrumentation , Intestinal Mucosa/metabolism , Male , Middle Aged , Oxygen/administration & dosage , Oxygen/pharmacokinetics , Oxygen/therapeutic use , Oxygen Inhalation Therapy/instrumentation , Pulmonary Gas Exchange/drug effectsABSTRACT
Purpose of the clinical case demonstration is to attract the professionals' attention to the method of enteral oxygen therapy successfully used in the complex intensive therapy of septic shock in young postpartum woman.
