ABSTRACT
The method of intermittent increasing normobaric isocapnic hypoxia was used for the treatment of bronchial asthma. The parameters of respiration, metabolism, free-radical processes and immune system were monitored before and after training. The therapeutic diagnostic complex "Hypotron" (Ukraine), which allowed to determine the individual reactivity of the patient's respiratory system, tolerance to hypoxia, and to choose an optimal program of treatment, was used. The hypoxic training resulted in considerable increase of lung vital capacity, maximal ventilation and forced expired velocity. Normalization of initially increased free radical processes, accompanied by a decrease in the lipid peroxidation products was observed. The hypoxic training positively influenced specific and nonspecific immunological status, and appeared to be associated with a far better stimulation of lymphocytes and neutrophils.
Subject(s)
Asthma/therapy , Hypoxia/physiopathology , Adult , Asthma/blood , Asthma/physiopathology , Combined Modality Therapy , Free Radicals/blood , Humans , Respiratory Therapy/instrumentation , Time FactorsABSTRACT
In experiments on intact rats it was established that dexamethasone and hydrocortisone induce biosynthesis of mitochondrial RNA in a similar way, the, action being of the phase character. Three maxima of RNA biosynthesis induction in the liver mitochondria were found. The first increase of RNA biosynthesis intensity in organelles was noted 15 minutes after administration of glucocorticoids, it was short-term and less pronounced than the subsequent ones. The maximal increase of mitochondrial RNA synthesis was observed at the 4th hour of the action of glucocorticoids (the 3rd phase). The increase of mitochondrial RNA synthesis intensity was associated with the decrease of the specific radioactivity of cytoplasmic RNA.
