[Thyroid state in workers of mechanical rubber production under complex exposure to occupational factors].

Complex study of thyroid gland covered workers engaged into mechanical rubber production, under exposure to complex of occupational factors. Chemical analytic study revealed 5.5 times excess of acrylonitrile content of expired air in examinees of the study group if compared to the reference group. Ultrasound examination data demonstrate structural changes in thyroid gland in 72% of the workers (diffuse changes and nodular masses). As early dysadaptation markers, findings are 1.3-1.7 times increased antibodies to TPO and higher TSH level. These disorders can indicate autoimmune processes in thyroid tissue and strain of compensatory adaptational mechanisms of pituitary-thyroid regulation.

[Clinical and laboratory diagnostic criteria of chronic glomerular and tubulointerstitial kidney disorders associated with exposure to metals and oxygen organic compounds of technogenic origin].

Complex clinical, functional an laboratory examination of children living under unacceptable risk conditions due to aerogenous exposure to cadmium, chromium, lead and phenol revealed that kidney diseases associated with exposure to metals and phenol develop in children with genetic predisposition to disordered biotransformation of chemicals--polymorphism of genes CYPOX, RCYT 450, SULTA1 in homozygous and heterozygous variants. Increased levels of chemicals in blood causes microcirculation disorders in renal cortex, direct toxic effect in nephrons, suppresses activity of anitoxidant defense on cellular and systemic levels. The authors specified pathogenetically based complex of clinical and laboratory diagnostic markers of chronic kidney diseases associated with exposure to metals (cadmium, chromium, lead) and oxygen-containing (phenol) organic compounds.