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1.
Nutr Metab Cardiovasc Dis ; 29(6): 633-638, 2019 06.
Article in English | MEDLINE | ID: mdl-30956026

ABSTRACT

BACKGROUND AND AIMS: Sunlight exposure is associated with a number of health benefits including protecting us from autoimmunity, cardiovascular disease, obesity and diabetes. Animal studies have confirmed that ultraviolet (UV)-B radiation, independently of vitamin D, can limit diet-induced obesity, metabolic syndrome and atherosclerosis. The aim of this study is to investigate whether exposure to the UV radiation contained in sunlight impacts on these disease parameters. METHODS AND RESULTS: We have trialled an intervention with solar UV in obese and atherosclerosis-prone mice. We have discovered that solar-simulated UV can significantly limit diet-induced obesity and reduce atheroma development in mice fed a diet high in sugar and fat. The optimal regime for this benefit was exposure once a week to solar UV equivalent to approximately 30 min of summer sun. Exposure to this optimal dose of solar UV also led to a significant increase in liver triglycerides which may protect the liver from damage. CONCLUSION: Our results show that the UV contained in sunlight has the potential to prevent and treat chronic disease at sites distant from irradiated skin. A major health challenge going forward will be to harness the power of the sun safely, without risking an increase in skin cancers.


Subject(s)
Adipose Tissue, Brown/radiation effects , Atherosclerosis/prevention & control , Diet, High-Fat , Liver/radiation effects , Obesity/prevention & control , Triglycerides/metabolism , Ultraviolet Therapy , Weight Gain/radiation effects , Adipose Tissue, Brown/metabolism , Adipose Tissue, Brown/physiopathology , Adiposity/radiation effects , Animals , Atherosclerosis/genetics , Atherosclerosis/metabolism , Atherosclerosis/pathology , Disease Models, Animal , Liver/metabolism , Male , Mice, Inbred C57BL , Mice, Knockout, ApoE , Obesity/etiology , Obesity/metabolism , Obesity/physiopathology , Uncoupling Protein 1/metabolism
2.
Obes Rev ; 19(3): 406-420, 2018 03.
Article in English | MEDLINE | ID: mdl-29243339

ABSTRACT

Adipose tissue plays a significant role in whole body energy homeostasis. Obesity-associated diabetes, fatty liver and metabolic syndrome are closely linked to adipose stress and dysfunction. Genetic predisposition, overeating and physical inactivity influence the expansion of adipose tissues. Under conditions of constant energy surplus, adipocytes become hypertrophic and adipose tissues undergo hyperplasia so as to increase their lipid storage capacity, thereby keeping circulating blood glucose and fatty acids below toxic levels. Nonetheless, adipocytes have a saturation point where they lose capacity to store more lipids. At this stage, when adipocytes are fully lipid-engorged, they express stress signals. Adipose depots (particularly visceral compartments) from obese individuals with a severe metabolic phenotype are characterized by the high proportion of hypertrophic adipocytes. This review focuses on the mechanisms of adipocyte enlargement in relation to adipose fatty acid and cholesterol metabolism, and considers how this may be related to adipose dysfunction.


Subject(s)
Adipocytes/pathology , Adipocytes/physiology , Fatty Acids/metabolism , Lipid Metabolism/physiology , Obesity/physiopathology , Overnutrition/physiopathology , Adipocytes/cytology , Adiposity , Humans , Inflammation Mediators/metabolism , Obesity/metabolism , Overnutrition/complications , Overnutrition/metabolism , Stress, Physiological
3.
Int J Obes (Lond) ; 35(12): 1539-48, 2011 Dec.
Article in English | MEDLINE | ID: mdl-21386801

ABSTRACT

OBJECTIVE: Fat Aussie mice (foz/foz) are morbidly obese, glucose intolerant and have liver steatosis that develops into steatohepatitis on a high-fat diet. The cannabinoid 1 receptor (CB1) antagonist SR141716 has been shown to improve obesity-associated metabolic complications in humans and rodent models. The aim of this study was to assess the effect of SR141716 in foz/foz mice. DESIGN: Male wildtype (WT) and foz/foz mice were fed a chow or high-fat diet (45% saturated fat). Vehicle or SR141716 (10 mg kg(-1) per day) was administered in jelly once daily for 4 weeks from 4 months of age. RESULTS: Foz/foz mice were obese but had less epididymal adipose tissue mass than fat-fed WT mice despite being significantly heavier. Liver weight was increased by twofold in foz/foz compared with WT mice and showed significant steatogenesis associated with impaired liver function. Foz/foz and fat-fed WT mice were glucose intolerant as determined by oral glucose tolerance test. In chow-fed foz/foz mice, SR141716 reduced body weight, liver weight, reversed hepatosteatosis and glucose intolerance. Subcutaneous white adipose tissue gene expression of the macrophage-specific marker Cd68 reflected the improvements in the metabolic status by SR141716 in these mice. CONCLUSION: The results are consistent with the hypothesis that foz/foz mice have defective lipid metabolism, are unable to adequately store fat in adipose tissue but instead sequester fat ectopically in other metabolic tissues (liver) leading to insulin resistance and hepatic steatosis associated with inflammation. Our findings suggest that SR141716 can improve liver lipid metabolism in foz/foz mice in line with improved insulin sensitivity and adipose tissue inflammation.


Subject(s)
Adipose Tissue/metabolism , Fatty Liver/drug therapy , Inflammation/drug therapy , Lipid Metabolism/drug effects , Liver/metabolism , Obesity, Morbid/drug therapy , Obesity, Morbid/metabolism , Piperidines/pharmacology , Pyrazoles/pharmacology , Receptor, Cannabinoid, CB1/antagonists & inhibitors , Adipose Tissue/drug effects , Adipose Tissue/pathology , Animals , Diet, High-Fat , Disease Models, Animal , Fatty Liver/metabolism , Fatty Liver/pathology , Glucose Intolerance/metabolism , Glucose Tolerance Test , Inflammation/etiology , Inflammation/metabolism , Inflammation/pathology , Insulin Resistance , Liver/drug effects , Liver/pathology , Male , Mice , Obesity, Morbid/complications , Rimonabant
4.
Int J Obes (Lond) ; 29(4): 398-405, 2005 Apr.
Article in English | MEDLINE | ID: mdl-15672109

ABSTRACT

OBJECTIVE: Leptin secretion has been shown to respond acutely to changes in blood glucose and insulin. Nutritional state also has a marked effect on both the level of circulating leptin protein and leptin gene expression. The aim of this study was to assess whether the prior nutritional state altered the leptin secretory response to an acute glucose challenge, and to determine potential mechanisms. DESIGN: Male fed or fasted rats (200-250 g) were administered a single intravenous glucose bolus (1, 4 or 7 g/kg). The serum leptin, glucose, insulin and free fatty acid responses were studied over the following 5 h. The level of leptin gene expression and leptin protein was then determined in the epididymal fat pads, and in fed and fasted untreated rats for basal comparison. RESULTS: Leptin secretion in response to glucose was suppressed in fasted rats following all glucose doses. The total leptin response was correlated with the total insulin response in all conditions (r = 0.85) and with the glucose response in fed rats (r = 0.69). Both leptin gene expression and leptin protein content were lower in basal fasted rats. Leptin gene expression and leptin protein content still remained lower 5 h following a glucose bolus but there was partial reversal of the effects of fasting following the 7 g/kg glucose dose. CONCLUSIONS: Leptin secretion in response to an intravenous glucose bolus was determined by the insulin response and was significantly suppressed in fasted compared to fed rats. In addition to differences in the total insulin response of the animals, lower leptin responses may be facilitated by lower levels of both leptin gene mRNA and pre-existing leptin protein in epididymal adipose tissue of fasted rats.


Subject(s)
Fasting/blood , Glucose , Insulin/blood , Leptin/blood , Adipose Tissue/chemistry , Animals , Blood Glucose/analysis , Depression, Chemical , Epididymis/chemistry , Fatty Acids, Nonesterified/blood , Gene Expression , Injections, Intravenous , Leptin/analysis , Leptin/genetics , Male , RNA, Messenger/analysis , Rats , Rats, Wistar , Reverse Transcriptase Polymerase Chain Reaction , Specific Pathogen-Free Organisms
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