ABSTRACT
The strain of Walker carcinosarcoma 256 described induces hypercalcaemia, hyperphosphataemia and hyperuraemia in tumour bearing rats. Changes in calcium and phosphorus excretion are observed as well as accompanying calcification of soft tissue organs and loss of bone calcium. These changes in calcium metabolism disappear after removal of the tumour, so that long-range action of the tumour can be stated. The results are discussed in comparison with three other animal models of tumour dependent hypercalcaemia.
Subject(s)
Carcinoma 256, Walker/blood , Hypercalcemia/etiology , Animals , Body Weight , Bone and Bones/metabolism , Calcium/metabolism , Calcium/urine , Carcinoma 256, Walker/metabolism , Female , Kidney/metabolism , Lung/metabolism , Myocardium/metabolism , Neoplasm Transplantation , Phosphates/blood , Phosphorus/blood , Phosphorus/urine , Rats , Spectrophotometry, Atomic , Time Factors , Urea/bloodABSTRACT
Rats were treated with lithium chloride over 6 weeks. During the experiment, determinations of serum calcium, magnesium and phosphorus revealed no changes due to the therapy. Postmortem examinations of liver, skeletal muscle, and femur minerals as well as bone histology showed these organs to be unaffected by lithium application. Only body weight gain was in part increased by lithium.
