ABSTRACT
Propranolol hydrochloride was administered to 30 patients with stable angina pectoris suffering from coronary heart disease (CHD). Of them 18 patients had ventricular extrasystole, 12 had ventricular tachycardia. All the patients underwent resting ECG, bicycle ergometry, transesophageal pacing, 24-h ECG monitoring. Vegetative cardiac regulation was determined using mathematical analysis of at least 100 successive intervals R-R at rest before and after therapy (120 mg day of propranolol hydrochloride). The authors estimated characteristics of the variance analysis and two secondary values--stress index and centralization index calculated by spectral characteristics of the rhythm. Only in CHD patients with ventricular tachycardia the treatment shifted the vegetative tone in the direction of parasympathetic nervous system. It is concluded that propranolol hydrochloride affects cardiac rhythm depending on the initial condition of vegetative regulation of cardiac activity.
Subject(s)
Autonomic Nervous System/drug effects , Cardiac Complexes, Premature/drug therapy , Heart Rate/drug effects , Myocardial Ischemia/drug therapy , Propranolol/therapeutic use , Tachycardia, Ventricular/drug therapy , Adult , Aged , Analysis of Variance , Cardiac Complexes, Premature/etiology , Cardiac Complexes, Premature/physiopathology , Drug Evaluation , Electrocardiography/drug effects , Electrocardiography/statistics & numerical data , Female , Humans , Male , Middle Aged , Myocardial Ischemia/complications , Myocardial Ischemia/physiopathology , Signal Processing, Computer-Assisted , Tachycardia, Ventricular/etiology , Tachycardia, Ventricular/physiopathologySubject(s)
Tachycardia/classification , Acute Disease , Heart Ventricles , Humans , Tachycardia/diagnosis , Tachycardia/etiology , Tachycardia/therapy , Tachycardia, Paroxysmal/classification , Tachycardia, Paroxysmal/diagnosis , Tachycardia, Paroxysmal/etiology , Tachycardia, Paroxysmal/therapy , Terminology as TopicABSTRACT
An analysis of data of contrast ventriculography before and after volume load tests in 19 males suffering of chronic alcoholism with disorders of intraventricular conduction revealed signs of alcohol involvement of the heart with signs of "latent" insufficiency of the right and left ventricles manifested in an increased rate of circular shortening of myocardial fibers, terminal diastolic and terminal systolic volumes, terminal diastolic pressure.
Subject(s)
Alcoholism/physiopathology , Arrhythmias, Cardiac/physiopathology , Heart/physiopathology , Adult , Alcoholism/complications , Alcoholism/diagnosis , Arrhythmias, Cardiac/diagnosis , Arrhythmias, Cardiac/etiology , Cardiomyopathy, Alcoholic/diagnosis , Cardiomyopathy, Alcoholic/etiology , Cardiomyopathy, Alcoholic/physiopathology , Heart Ventricles/physiopathology , Hemodynamics/physiology , Humans , Male , Middle Aged , Myocardial Contraction/physiologyABSTRACT
Forty patients aged 33 to 66 years suffering from chronic alcoholism, stages II-III, were examined. All the patients were subjected to contrast ventriculography before and after exercise test to identify the latent forms of heart failure. According to the coronarography findings, 9 out of the 40 patients demonstrated the signs of atherosclerotic injury to the coronary arteries. The data of endomyocardial biopsy of the left ventricle have shown morphologic changes characteristic of alcohol-induced heart injury, namely atrophy of cardiomyocytes, fat deposition in the interstitium, lysis of myofibrils, appearance of large vacuoles in cardiomyocytes, and mitochondriosis.
