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Kardiologiia ; 28(5): 80-3, 1988 May.
Article in Russian | MEDLINE | ID: mdl-2900910

ABSTRACT

Data on clopheline effect on platelet aggregation, both spontaneous and ADP- or adrenaline-induced, in normal donors are reported. Clopheline is shown to slightly increase aggregation in normal subjects, exhibiting properties of a weak aggregation inductor. Where adrenaline is present in the aggregating system, clopheline undermines its platelet aggregation-inducing effect and, consequently, shows properties of a more competitive antagonist, as compared to adrenaline.


Subject(s)
Adrenergic alpha-Agonists/pharmacology , Clonidine/pharmacology , Platelet Aggregation/drug effects , Adult , Humans , In Vitro Techniques , Middle Aged
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