ABSTRACT
The paper outlines a new mode of intravascular anabolic steroidal transport. The single intravenous administration of metandrostenolone aqueous solution to rats increases hypertrophy rate of MM. plantaris. It was shown that the action of a single dose (0.05 mg/kg) exceeded that of metandrostenolone oil solution in a dose of 5 mg/kg. The multiple reduction of doses of the anabolic drug and the high level of bioavailability were achieved. This effect was explained by the application of the specific transport agent.
Subject(s)
Blood/drug effects , Methandrostenolone/pharmacology , Muscles/drug effects , Muscles/pathology , Animals , Blood/metabolism , Dose-Response Relationship, Drug , Hypertrophy/blood , Hypertrophy/etiology , Male , Methandrostenolone/administration & dosage , Methandrostenolone/blood , Rats , Rats, Wistar , Solubility , Time FactorsABSTRACT
The rat experiments were made to compare the wound-healing action of solubilized (aqueous) alpha-tocopherol acetate (SATA) prepared by the original techniques and its official oil-based preparation. A course intravenous SATA (2 mg four times at an interval of 4 days) administration was found to stimulate epithelial regeneration and suppress the formation of connective tissue of uncomplicated skin wounds. By healing the complicated wounds, SATA potentiated the occurrence of an inflammatory reaction and slowed down regeneration, whereas its oily solution failed to produce this effect.
Subject(s)
Antioxidants/pharmacology , Vitamin E/analogs & derivatives , Wound Healing/drug effects , alpha-Tocopherol/analogs & derivatives , Animals , Antioxidants/administration & dosage , Male , Rats , Skin/drug effects , Skin/injuries , Skin/pathology , Solubility , Time Factors , Tocopherols , Vitamin E/administration & dosage , Vitamin E/pharmacologyABSTRACT
A single intravenous administration of solubilized alpha-tocopherol acetate in a dose of 1 mg/kg to CBA x C57Bl x F1 male mice 3 and 24 hours before radiation was demonstrated to increase 30-day survival rates in the animals. Oily alpha-tocopherol acetate had the identical effects when the agent was intramuscularly given in a dose of 10 mg/kg. There was a rise in peripheral leukocyte counts 0.5 hour after solubilized alpha-tocopherol acetate administration. The antioxidative activity of the solubilized agent was 3.3 times as high as that the routine agent when attacking Tween 80. The higher radioprotective activity of solubilized alpha-tocopherol acetate is accounted for by its enhanced bioavailability, antioxidative activity and effects on the factors of nonspecific body's resistance.
Subject(s)
Antioxidants/administration & dosage , Radiation-Protective Agents/administration & dosage , Vitamin E/analogs & derivatives , alpha-Tocopherol/analogs & derivatives , Animals , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Injections, Intravenous , Male , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Radiation Injuries, Experimental/drug therapy , Radiation Injuries, Experimental/mortality , Solubility , Time Factors , Tocopherols , Vitamin E/administration & dosageABSTRACT
A single intravenous injection of solubilized alpha-tocopherol acetate to Wistar male rats in doses of 25, 50 and 100 mg/kg noticeably increased the animals' working capacity. The stimulation effect appeared 18 hours after the injection and was observable for two weeks. Utilization of glucose reserves in bioenergy supply of muscle activity has been shown. The maintenance of the action for such a long time may be accounted for by high metabolic stability of solubilized alpha-tocopherol acetate.
