Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 9 de 9
Filter
Add more filters










Database
Publication year range
1.
Bull Exp Biol Med ; 158(5): 617-20, 2015 Mar.
Article in English | MEDLINE | ID: mdl-25778646

ABSTRACT

Fas-induced apoptosis plays an important role in the mechanisms of tissue injury in myocardial infarction. The level of membrane Fas mRNA was elevated during the postinfarction period in the blood of patients and did not change in response to levocarnitine. The mRNA level of soluble Fas, inhibiting Fas-dependent apoptosis, remained normal during the first 7 days, but increased 14 days after myocardial infarction, which corresponded to previously detected increase of serum level of soluble Fas molecules. Addition of levocarnitine, inhibiting Fas-dependent apoptosis, to therapy caused no changes in the level of soluble Fas mRNA, presumably because of similar effects of soluble Fas and levocarnitine on the apoptotic processes in myocardial infarction.


Subject(s)
Carnitine/therapeutic use , Myocardial Infarction/blood , Myocardial Infarction/drug therapy , RNA, Messenger/blood , fas Receptor/genetics , Fas Ligand Protein/metabolism , Humans , Real-Time Polymerase Chain Reaction , fas Receptor/metabolism
2.
Probl Tuberk Bolezn Legk ; (8): 34-8, 2008.
Article in Russian | MEDLINE | ID: mdl-18819336

ABSTRACT

The levels of interferon-y (IFN-gamma), tumor necrosis factor-gamma (TNF-alpha), and interleukin-8 (IL-8) and their changes during chemotherapy and laser chemotherapy were studied in 97 patients with active infiltrative pulmonary tuberculosis, by taking into account Mycobacterium tuberculosis (MBT) sensitivity to chemical agents. The studies have indicated that the levels of IFN-gamma, TNF-alpha, and IL-8 are increased and may be markers of an active process. Chemotherapy causes a reduction in increased cytokinemia. Complex laser chemotherapy affects the cytokine profile in active tuberculosis caused by not only drug-sensitive, but also drug-resistant MBT.


Subject(s)
Cytokines/blood , Tuberculosis, Pulmonary/blood , Adolescent , Adult , Aged , Biomarkers/blood , Disease Progression , Female , Humans , Immunoassay , Male , Middle Aged , Severity of Illness Index , Tuberculosis, Pulmonary/diagnosis , Young Adult
SELECTION OF CITATIONS
SEARCH DETAIL
...