ABSTRACT
With the help of scanning electronic and atomic force microscopy structure of red blood cell membranes of the system blood-groove and microcirculatory channels is studied. It is established, that in early stages of skin wounds in a peripheral blood circulation appear compressed red blood cells, losing water. As a result the basic mechanism of destruction of red blood cell membranes are interlayered shifts and stratification. In red blood cells of microvasculature, on the contrary, red blood cells in state of vacuolar degeneration are indentified. It creates preconditions for hydration and bullous deformations of membranes. Porous structures of membranes of both types erythrocytes are exposed to expansion.
Subject(s)
Cytosol/ultrastructure , Erythrocytes/chemistry , Intracellular Membranes/ultrastructure , Skin/injuries , Skin/ultrastructure , Wounds and Injuries , Dermatologic Surgical Procedures , Early Medical Intervention , Erythrocyte Membrane/ultrastructure , Humans , Microscopy, Atomic Force , Microscopy, Electron, Scanning , Specimen Handling , Wounds and Injuries/blood , Wounds and Injuries/pathology , Wounds and Injuries/surgeryABSTRACT
The main facets of professor N.I. Pirogov's professional activity are outlined. Forensic medicine (in the first place its organizational and practical aspects) was an integral component of his scientific and clinical work, along with applied anatomy and surgery. Landmark publications of N.I. Pirogov are listed with special reference to those concerned with forensic medical expertise of medical malpractice cases, postmortem inspection and intravital examination procedures, wound ballistics studies, the atlas of forensic pathology, etc. The surgeon and anatomist N.I. Pirogov can be justly regarded as a founder of forensic medicine in this country.
