[Mathematical model of induced mutagenesis in bacteria Escherichia coli under ultraviolet irradiation].

The mathematical model of mutational process in bacteria Escherichia coli induced by ultra-violet radiation is developed. The dynamics of the basic protein complexes of the E. coli SOS-response system is investigated. The probability of mutations occurring during translesion-synthesis is estimated.

[The intensive therapy of posthypoxic encephalopathy]. / Intensivnaia terapiia postgipoksicheskoi éntsefalopatii.

A complex of therapeutic measures including hyperbaric oxygenation combined with heparin and endolumbal injection of glucocorticoids, proteolysis inhibitors, was carried out in 49 patients aged 16 to 95 with posthypoxic encephalopathy caused by mechanical asphyxia (11 patients,) carbon monoxide (12 cases), narcotics (18 cases), and closed craniocerebral injury (8 patients). Lipid peroxidation, some parameters of homeostasis, electrolyte, acid-base, and gaseous composition of the blood and liquor were studied before and during treatment. Positive clinical results were attained in 88.6% cases. Multiple-modality treatment of this patient population led to normalization of the coagulation potential of the blood and of the content of fibrinogen, but did not appreciably affect the electrolyte balance, acid-base, and gaseous composition of the blood. The activity of superoxide dismutase normalized, but the concentration of malonic dialdehyde increased, with the levels of dienic conjugates and nonerythrocytic hemoglobin being unchanged; however, the metabolic acidosis in the liquor still persisted.

[Effects of hyperoxia regimes on the state of lipid peroxidation and hemostasis in patients with lesions of the central nervous system]. / Vliianie rezhimov giperoksii na sostoianie perekisnogo okisleniia lipidov i gemostaz u bol'nykh s porazheniiami tsentral'noi nervnoi sistemy.

Lipid peroxidation and some parameters of hemostasis were studied during exposure to various hyperoxia schemes combined with heparin therapy before and after treatment in 124 patients aged 16 to 69 with CNS involvement which developed as a result of atherosclerosis and essential hypertension, 60 of whom presented with initial manifestations of cerebral circulation insufficiency (IMCCI), 33 with posthypoxic encephalopathies (PE), and 31 with ischemic stroke (IS). Hyperoxia mechanisms were differently directed in the studied groups of patients, this necessitating a differentiated approach to the choice of schemes of hyperbaric oxygenation. Use of a short course of hyperbaric oxygenation (up to 3 sessions at 1.2 to 1.25 atA) is recommended for patients with IMCCI and PE. For patients with IS in the acute period hyperbaric oxygenation at 1.4 atA is advisable combined with heparin therapy in doses of 150 to 300 U/kg b.w. a day.