Soluble B7-H3 in Ovarian Cancer and Its Predictive Value.

The content of the soluble form of protein of the key point of immunity B7-H3 (sB7-H3) in the blood plasma of 75 patients with epithelial ovarian cancer before treatment was measured by ELISA. It is known that B7-H3 belongs to the immunoglobulin superfamily (B7 molecule family) and is involved in the regulation of the immune response mediated by T cells. The sB7-H3 concentration correlated with the clinical and morphological parameters of ovarian cancer. The content of sB7-H3 was higher at the later stages of the disease, in the presence of ascites, and in patients with poorly differentiated ovarian cancer. It was revealed that increased plasma content of sB7-H3 in patients with epithelial ovarian cancer is associated with unfavorable prognosis of the disease. Therefore, sB7-H3 can be used as a prognostic marker in ovarian cancer patients.

Soluble forms of immune checkpoints in ovarian cancer.

The data of a complex immunoassay comparative study of the content of soluble forms of sPD-1, sPD-L1, sNKG2D, sNKG2DL1, sB7-H3 and sHLA-G in the blood plasma of 75 patients with epithelial ovarian cancer and 20 healthy donors of the control group are presented. The diagnostic significance of the studied proteins was determined. The study showed that the profile of soluble immunity checkpoints differs when malignant ovarian pathology occurs. There was a statistically significant decrease in the content of sPD-L1, sNKG2DL1, sB7-H3, and sHLA-G in the blood plasma of patients compared with the control group. Differences were found in the content of the studied markers depending on the histological type of tumors. Correlations between the soluble forms of some of the studied proteins are shown, indicating the presence of independent mechanisms of immune regulation in ovarian cancer, which may explain the insufficient effectiveness of the existing immunotherapy for this type of tumor. The results obtained will undoubtedly facilitate the development of new effective methods for the diagnostics and therapy of ovarian cancer.

Boron concentration by industrial anion exchanger resins from model solutions in a dynamic mode.

Kamchatka geothermal fields should be considered not only as heat and energy resources but also as possible sources of chemical compounds. Boron is one of such chemical elements. The Pauzhetskaya, Nalychevskoe, Pushchinskoe, Kireunskoe steam-hydrothermal fields are the most promising for boron recovery. Data obtained from experimental studies on boric acid sorption using the industrial ion exchangers KU-2-8, AV-17-8, EDE-10P, and AN-31 are presented in this article. The experiments are conducted in a dynamic mode, and the results showed that the method of sequential/consecutive two-stage sorption is most effective for: 1 - removal of the main part of cations using KU-2-8 cation exchanger; 2 - boric acid recovery using weakly basic AN-31 anion exchanger. The sorption capacity of the studied anion exchangers increases in the order as follows: AV-17-8

Adsorption of heavy metal ions (Cu2+, Ni2+, Co2+ and Fe2+) from aqueous solutions by natural zeolite.

The process of remove copper, nickel, cobalt and iron ions by natural zeolite of the Yagodninsky deposits, Kamchatka region, from water resources within a concentration range of 0.5-3.5 mg-eq/L has been experimentally investigated. The specified concentrations range was chosen according the contents of heavy metals in the waste water of the mining enterprise of Kamchatka region The values of maximum sorption capacity have been determined. On the basis of studies using X-ray powder diffraction (XRD) it has been established by the Rietveld method of calculation that the zeolite tuff of the Yagodninsky deposit consists of clinoptilolite-Na (23.0 %), clinoptilolite-Ca (52.1 %) and modernite (12.9 %). It has been established that exchange cations are sodium, calcium, potassium and magnesium. The Gibbs free energy has been calculated which is equal for copper ΔG = -25.6 kJ/mol, iron - ΔG = -23.7 kJ/mol, nickel - ΔG = -21.5 kJ/mol and cobalt - ΔG = -20.0 kJ/mol. The obtained results show that natural zeolite can be used as an effective sorbent for extracting of ions Cu2+, Ni2+, Co2+ and Fe2+ from polluted waters. On the basis of the analysis of the parameters of the mordenite crystal lattice a decrease in sizes in the direction of the a- and b-axes and, consequently, of the elementary cell volume of the treated zeolite is observed as compared with the initial zeolite in the Cu > Ni > Co > Fe row. New knowledge about the sorption properties of the Yagodninsky deposit zeolites can be interesting for the industrial areas of South-Eastern Asia such as China, Japan, Korea, etc.