[Pharmacodynamics and results of a clinical trial of nitrogranulong, a new Soviet long-acting preparation of nitroglycerin]. / Farmakodinamika i rezul'taty klinicheskogo izucheniia nitrogranulonga--novogo otechestvennogo prolongirovannogo preparata nitroglitserina.

In the USSR, the Research and Production Association "Vitamins" and the Department of Pharmacology, All-Union Research Institute of Medicinal Plants were the first to develop commercial processes for manufacturing trinitroglycerol microgranules on the basis of the raw material available in this country and to design the new long-acting drug Nitrogranulong. Experimental examinations revealed that Nitrogranulong showed the same bioavailability as Nitro-Mack-Retard and sustac, produced a prolonged coronarolytic effect, and caused the hemodynamic and ECG changes typical of trinitroglycerol. The agent was found to be low toxic and well tolerated in a dosage form. Clinical examination of 467 patients indicated that Nitrogranulong exhibited the same antianginal potency, but in some cases it was superior to sustac, nitrong, 2% nitroglycerin ointment, and nitrosorbide. The agent caused significantly less adverse and toxic effects. Nitrogranulong is used in medical practice to prevent anginal episodes. It is produced in tablets in two dosages (2.9 and 5.2 mg trinitroglycerol), its action duration being 7-8 hours.

[Role of vitamins in the prevention of atherosclerosis]. / K voprosu o roli vitaminov v profilaktike ateroskleroza

Persons doing brain work and taking aerovit in three courses of 30 days each with intervals of 5-6 months were kept under observation over a period of 13-15 months. While improving the vitamin allowance the course-wise taking of aerovit helped normalize the lipids metabolism factors characterizing an increased predisposition to atherosclerosis, the favourable effect being traced for 4-5 months after discontinuance of the preparation ingestion. Repeated courses contributed to a further improvement of the lipoid metabolism. A tendency towards positive changes in the tonicity of the intracranial vessels was recorded, while in subjects with an increased pulse wave propagation rate along the elastic type vessels this tonicity was seen to decline. With the available data on the positive effect of aerovit upon the lipoid and protein metabolism and some clinical and instrumental findings serving as a background an inference is made that a prolonged (course-wise) application of aerovit can be of help in preventing the development of atherosclerosis.