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1.
Intensive Care Med ; 40(7): 981-7, 2014 Jul.
Article in English | MEDLINE | ID: mdl-24852952

ABSTRACT

PURPOSE: To evaluate the psychological consequences among family members given the option to be present during the CPR of a relative, compared with those not routinely offered the option. METHODS: Prospective, cluster-randomized, controlled trial involving 15 prehospital emergency medical services units in France, comparing systematic offer for a relative to witness CPR with the traditional practice among 570 family members. Main outcome measure was 1-year assessment included proportion suffering post-traumatic stress disorder (PTSD), anxiety and depression symptoms, and/or complicated grief. RESULTS: Among the 570 family members [intention to treat (ITT) population], 408 (72%) were evaluated at 1 year. In the ITT population (N = 570), family members had PTSD-related symptoms significantly more frequently in the control group than in the intervention group [adjusted odds ratio, 1.8; 95% confidence interval (CI) 1.1-3.0; P = 0.02] as did family members to whom physicians did not propose witnessing CPR [adjusted odds ratio, 1.7; 95% CI 1.1-2.6; P = 0.02]. In the observed cases population (N = 408), the proportion of family members experiencing a major depressive episode was significantly higher in the control group (31 vs. 23%; P = 0.02) and among family members to whom physicians did not propose the opportunity to witness CPR (31 vs. 24%; P = 0.03). The presence of complicated grief was significantly greater in the control group (36 vs. 21%; P = 0.005) and among family members to whom physicians did not propose the opportunity to witness resuscitation (37 vs. 23%; P = 0.003). CONCLUSIONS: At 1 year after the event, psychological benefits persist for those family members offered the possibility to witness the CPR of a relative in cardiac arrest.


Subject(s)
Cardiopulmonary Resuscitation/psychology , Family/psychology , Heart Arrest/therapy , Intention to Treat Analysis , Adult , Anxiety/epidemiology , Depression/epidemiology , Emergency Medical Services , Follow-Up Studies , France/epidemiology , Grief , Humans , Prospective Studies , Stress Disorders, Post-Traumatic/epidemiology
2.
N Engl J Med ; 368(11): 1008-18, 2013 Mar 14.
Article in English | MEDLINE | ID: mdl-23484827

ABSTRACT

BACKGROUND: The effect of family presence during cardiopulmonary resuscitation (CPR) on the family members themselves and the medical team remains controversial. METHODS: We enrolled 570 relatives of patients who were in cardiac arrest and were given CPR by 15 prehospital emergency medical service units. The units were randomly assigned either to systematically offer the family member the opportunity to observe CPR (intervention group) or to follow standard practice regarding family presence (control group). The primary end point was the proportion of relatives with post-traumatic stress disorder (PTSD)-related symptoms on day 90. Secondary end points included the presence of anxiety and depression symptoms and the effect of family presence on medical efforts at resuscitation, the well-being of the health care team, and the occurrence of medicolegal claims. RESULTS: In the intervention group, 211 of 266 relatives (79%) witnessed CPR, as compared with 131 of 304 relatives (43%) in the control group. In the intention-to-treat analysis, the frequency of PTSD-related symptoms was significantly higher in the control group than in the intervention group (adjusted odds ratio, 1.7; 95% confidence interval [CI], 1.2 to 2.5; P=0.004) and among family members who did not witness CPR than among those who did (adjusted odds ratio, 1.6; 95% CI, 1.1 to 2.5; P=0.02). Relatives who did not witness CPR had symptoms of anxiety and depression more frequently than those who did witness CPR. Family-witnessed CPR did not affect resuscitation characteristics, patient survival, or the level of emotional stress in the medical team and did not result in medicolegal claims. CONCLUSIONS: Family presence during CPR was associated with positive results on psychological variables and did not interfere with medical efforts, increase stress in the health care team, or result in medicolegal conflicts. (Funded by Programme Hospitalier de Recherche Clinique 2008 of the French Ministry of Health; ClinicalTrials.gov number, NCT01009606.).


Subject(s)
Cardiopulmonary Resuscitation/psychology , Emergency Medical Services , Family/psychology , Heart Arrest/therapy , Stress Disorders, Post-Traumatic/etiology , Aged , Anxiety/etiology , Comorbidity , Depression/etiology , Female , Follow-Up Studies , Humans , Intention to Treat Analysis , Male , Middle Aged , Single-Blind Method , Stress Disorders, Post-Traumatic/diagnosis , Stress Disorders, Post-Traumatic/epidemiology
3.
Emerg Med J ; 30(12): 1038-42, 2013 Dec.
Article in English | MEDLINE | ID: mdl-23221456

ABSTRACT

OBJECTIVE: To assess the practices and opinions of prehospital emergency medical services (EMS) with regard to family witnessed resuscitation (FWR) and to analyse the differences between physicians' and nurses' responses. DESIGN: An anonymous questionnaire (30 yes/no questions on demographics and FWR) was sent to all prehospital emergency staff (physicians, nurses and support staff) working for the 377 Mobile Intensive Care Units in France. RESULTS: Of the 2689 responses received 2664 were analysed. Mean respondent age was 38 ± 8 years, the male to female ratio was 1:2. 87% of respondents had already performed FWR and 38% had offered relatives the option to be present during resuscitation. Most respondents (90%) felt that FWR might cause psychological trauma to the family; 70% thought that FWR might impact on the duration of resuscitation and 68% on EMS team concentration. In the 28% of cases when relatives had asked to be present, 59% of respondents had acquiesced but only 27% were willing to invite relatives to be routinely present. CONCLUSIONS: Prehospital EMS teams in France seems to support FWR but are not yet ready to offer it systematically to relatives. Following our survey, written guidelines are currently in development in our department. These guidelines could be the first step of a national strategy for developing FWR in France. We await results from other studies of family members' opinions to compare prehospital practitioners' and family members' views to further develop our practice.


Subject(s)
Attitude of Health Personnel , Cardiopulmonary Resuscitation/psychology , Emergency Medical Services , Family/psychology , Visitors to Patients/psychology , Adult , Cardiopulmonary Resuscitation/methods , Female , France , Health Surveys , Humans , Male , Middle Aged , Professional-Family Relations , Surveys and Questionnaires
4.
Intensive Care Med ; 37(9): 1501-9, 2011 Sep.
Article in English | MEDLINE | ID: mdl-21805159

ABSTRACT

PURPOSE: Continuous positive airway pressure (CPAP) is a useful treatment for patients with acute cardiogenic pulmonary oedema (CPE). However, its usefulness in the out-of-hospital setting has been poorly investigated and only by small and single-centre studies. We designed a multicentre randomised study to assess the benefit of CPAP initiated out of hospital. METHODS: A total of 207 patients with CPE were randomly allocated by emergency mobile medical units to receive either standard treatment alone or standard treatment plus CPAP. CPAP was maintained after admission to the intensive care unit (ICU). Inclusion criteria were orthopnoea, respiratory rate greater than 25 breaths/min, pulse oximetry less than 90% in room air and diffuse crackles. The primary end point was assessed during the first 48 h and combined: death, presence of intubation criteria, persistence of either all inclusion criteria or circulatory failure at the second hour or their reappearance before 48 h. Absence of all criteria defined successful treatment. RESULTS: CPAP was used for 60 min [40, 65] (median [Q1, Q3]) in the pre-hospital setting and 120 min [60, 242] in ICU and was well tolerated in all patients. Treatment was successful in 79% of patients in the CPAP group and 63% in the control group (p = 0.01), especially for persistence of inclusion criteria after 2 h (12 vs. 26%) and for intubation criteria (4 vs. 14%). CPAP was beneficial irrespective of the initial PaCO(2) or left ventricular ejection fraction. CONCLUSION: Immediate use of CPAP in out-of-hospital treatment of CPE and until CPE resolves after admission significantly improves early outcome compared with medical treatment alone.


Subject(s)
Continuous Positive Airway Pressure , Intensive Care Units , Out-of-Hospital Cardiac Arrest , Pulmonary Edema/therapy , Acute Disease , Aged , Aged, 80 and over , Female , France , Humans , Male , Prospective Studies , Pulmonary Edema/physiopathology
5.
J Emerg Med ; 39(5): 623-8, 2010 Nov.
Article in English | MEDLINE | ID: mdl-19062222

ABSTRACT

BACKGROUND: Prehospital emergency care providers have very little information regarding fetal perfusion adequacy in the field. OBJECTIVE: This study was conducted to evaluate the feasibility of the use of fetal monitoring in the prehospital setting. METHODS: A mobile cardiotocometer was used for all consecutive pregnant women managed by our physician-staffed Emergency Medical Services unit. The visualization of interpretable tracings (both fetal heart rate and tocography) at the different stages of prehospital management was evaluated. Any change in a patient's management was also recorded. RESULTS: There were 145 patients enrolled during 119 inter-hospital transfers and 26 primary prehospital interventions. Interpretable tracings were obtained for 81% of the patients during the initial examination. This rate decreased to 66% during handling and transfer procedures. For 17 patients (12%), the monitoring led to a change in the patient's management. CONCLUSION: This study shows that cardiotocography can be easily performed in the prehospital setting, and is usually feasible. Moreover, the study demonstrates a positive impact of fetal heart rate monitoring on prehospital management.


Subject(s)
Cardiotocography , Emergency Medical Services , Fetal Monitoring , Adolescent , Adult , Feasibility Studies , Female , Fetal Monitoring/statistics & numerical data , Humans , Middle Aged , Pregnancy , Prospective Studies , Young Adult
6.
J Emerg Med ; 34(3): 305-10, 2008 Apr.
Article in English | MEDLINE | ID: mdl-17933482

ABSTRACT

This study was carried out to evaluate the compliance with a morphine protocol and its effects on pain relief in pre-hospital care. In this prospective study, pain intensity was evaluated by the Visual Analog Scale (VAS) from the beginning and every 5 min until hospital arrival (Tend). Group 1: No major deviation from the protocol (intravenous morphine as a first bolus of 0.05 mg/kg followed by repeated boluses every 5 min until VAS < or = 30 mm). Group 2: Major deviation from the protocol. There were 216 patients included. The mean dose of morphine was 9.0 +/- 5.7 mg. The morphine protocol was respected in 123 patients (57%). The mean VAS score was significantly better at Tend in Group 1 vs. Group 2 (27.8 +/- 21.1 mm vs. 37.8 +/- 22.1 mm, respectively), the degree of pain relief was significantly better (73% vs. 53%, respectively) and the initiation time for pain relief was significantly shorter in Group 1 vs. Group 2 (10 min [5-15] vs. 15 min [10-26], respectively). Satisfaction was significantly better in patients expressing pain relief than in unrelieved patients (94% vs. 61%, respectively). Out-of-hospital pain management using morphine depends on careful attention to dosage and the time interval between re-injections. Emergency teams may employ these data to improve the quality of pain relief in the field.


Subject(s)
Analgesics, Opioid/administration & dosage , Emergency Medical Services/statistics & numerical data , Guideline Adherence/statistics & numerical data , Morphine/administration & dosage , Pain/drug therapy , Analgesics, Opioid/adverse effects , Female , France , Humans , Male , Middle Aged , Morphine/adverse effects , Pain/classification , Pain Measurement , Patient Satisfaction , Prospective Studies , Time Factors
7.
Am J Emerg Med ; 23(7): 852-9, 2005 Nov.
Article in English | MEDLINE | ID: mdl-16291440

ABSTRACT

INTRODUCTION: This study was carried out to estimate the relationship between arterial PCO2 (PaCO2) and end-tidal carbon dioxide (PETCO2) during prehospital controlled ventilation and also to evaluate variation of the gradient between PCO2 and PETCO2 during prehospital transport. METHODS: Measurements of PETCO2 from capnography values and PaCO2 from arterial blood gases were registered at the beginning (T(0)) and at the end (T(end)) of out-of-hospital management. For all patients requiring invasive ventilation, the gradient between PCO2 and PETCO2 was calculated for T(0) and T(end), the PaCO2-PETCO2 variation between T(end) and T(0) was also calculated. RESULTS: One hundred patients were included in this study (mean age, 58.4 +/- 16.4 years; 57 were male). There was no variation of the mean gradient (DeltaPaCO2-PETCO2 ) during transport (8.64 +/- 13.5 mm Hg at T(0) and 7.26 +/- 12.94 mm Hg at T(end)). Thirty-six percent of patients (n = 36) had a gradient above +10 mm Hg, and for 6% of patients (n = 4) the gradient was lower than -10 mm Hg. The PaCO2-PETCO2 gradient was not significantly different according to the pathology, but was significantly higher in hypercapnic patients compared with hypocapnic or normocapnic patients. In patients with severe head injury, the capnia was normalized in 80% of patients at the end of the transport according to the last blood gas result. In this subgroup the DeltaPaCO2-PETCO2 (T(end) - T(0)) gradient was stable between T(0) and T(end) except in 20% of the patients for whom the DeltaPaCO2-PETCO2 was lower than -10 mm Hg. Fifty-four percent of critical care physicians had modified the respiratory setting after the first arterial blood gas results. CONCLUSIONS: The PaCO2 cannot be estimated by the PETCO2 in the prehospital setting. There is wide variation in the gradient between PCO2 and PETCO2 depending on patient condition, and over time, the relationship does not remain constant and thus cannot be useful in prehospital ventilation management.


Subject(s)
Carbon Dioxide/blood , Respiration, Artificial , Transportation of Patients , Adult , Aged , Blood Gas Analysis , Capnography , Female , Humans , Male , Middle Aged , Partial Pressure , Prospective Studies , Reproducibility of Results , Tidal Volume
8.
Am Heart J ; 148(3): 378-85, 2004 Sep.
Article in English | MEDLINE | ID: mdl-15389222

ABSTRACT

BACKGROUND: Most patients with acute myocardial infarction (AMI) are admitted to hospitals without percutaneous transluminal coronary angioplasty (PTCA) facilities or are initially managed in a prehospital mobile unit. Thrombolysis remains the most readily available reperfusion treatment in those settings, but the optimal subsequent strategy in those patients is unclear. If a mechanical recanalization is likely to be performed in an emergency, it is probably desirable that the patient receives abciximab, the glycoprotein IIb/IIIa antagonist with the strongest evidence of benefit for angioplasty in AMI. OBJECTIVE: The aim of this trial is to compare the effects on clinical outcome and cost-effectiveness of 2 strategies after immediate treatment with abciximab and half-dose reteplase for ST-elevation AMI: to manage the patients conservatively (referring them for rescue PTCA only if needed) or to immediately send all patients for emergency coronary angioplasty. METHODS: The Combined Abciximab RE-teplase Stent Study in Acute Myocardial Infarction (CARESS in AMI) is an open, prospective, randomized, multicenter clinical trial conducted in patients with high-risk ST-segment elevation AMI treated within 12 hours from symptom onset in hospitals without PTCA facilities or in a prehospital mobile intensive care unit. Apart from contraindications to thrombolysis, the main exclusion criteria are age > or =75 years and a past history of CABG surgery or a percutaneous coronary intervention procedure involving the infarct-related artery. Enrollment will be performed in hospitals without PTCA facilities or directly in the ambulance if a dedicated system is in place for prehospital diagnosis and treatment of AMI. Patients will receive half-dose reteplase and full-dose abciximab and will subsequently be randomized to conventional medical therapy (with referral for emergency rescue PTCA allowed in selected cases) or emergency angioplasty. The primary end point is the 30-day combined incidence of mortality, reinfarction, and refractory ischemia. In order to obtain a 95% power (2-sided) to detect a 42% reduction in the primary end point, 900 patients are required in each arm of the study. Secondary end points include the 1-year composite end point of mortality, reinfarction, refractory ischemia, and hospital readmission because of heart failure; resource use at 30 days and 1 year; and the incidence of inhospital stroke and bleeding complications in the 2 groups. RESULTS: Seventy-four patients have been randomized (as of March 10, 2004); results are expected in June 2005. CONCLUSION: This study will establish whether angioplasty must be started as soon as possible in all patients who receive combined pharmacologic reperfusion with the glycoprotein IIb/IIIa inhibitor abciximab and half-dose thrombolysis or whether it can be postponed or skipped in patients with signs of successful reperfusion, with obvious organizational advantages.


Subject(s)
Antibodies, Monoclonal/therapeutic use , Immunoglobulin Fab Fragments/therapeutic use , Myocardial Infarction/drug therapy , Plasminogen Activators/therapeutic use , Recombinant Proteins/therapeutic use , Thrombolytic Therapy , Tissue Plasminogen Activator/therapeutic use , Abciximab , Cost-Benefit Analysis , Drug Therapy, Combination , Emergency Medical Services , Humans , Myocardial Infarction/mortality , Myocardial Infarction/therapy , Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors , Prospective Studies , Recurrence , Stents , Treatment Outcome
9.
Am J Emerg Med ; 21(6): 461-6, 2003 Oct.
Article in English | MEDLINE | ID: mdl-14574652

ABSTRACT

The aim of this study was to introduce a continuous monitoring of side effects related to sedation-analgesia in the field. A document was completed by physicians on board the ambulances for all prehospital interventions and checked daily by the medical staff. A total of 3605 interventions were evaluated over a 12-month period. Six hundred four patients undertook analgesia and/or sedation: group 1 (spontaneously breathing patients) n = 289 and group 2 (intubated-ventilated patients) n = 315. Sixty-four percent of patients received intravenous opioids in group 1. The anesthetic technique used for intubation was the rapid sequence induction in 70% of patients. Side effects were observed in 5.5% in group 1 (nausea: 2%, hypotension: 1%, hypoxemia: 1%) and 22% of patients in group 2 (hypotension-arrhythmia: 12%, cardiac arrest: 2%, difficult intubation: 5%, hypoxemia: 1%, pulmonary aspiration: 1%, laryngospasm/bronchospasm: 2%). No death was related to these medications. A close monitoring of side effects related to sedation-analgesia must be included in a quality program to improve patient safety in the field.


Subject(s)
Analgesia/adverse effects , Analgesia/statistics & numerical data , Conscious Sedation/adverse effects , Conscious Sedation/statistics & numerical data , Emergency Medical Services/statistics & numerical data , Adult , Comorbidity , Female , France/epidemiology , Heart Arrest/epidemiology , Humans , Hypotension/epidemiology , Intubation, Intratracheal/statistics & numerical data , Male , Middle Aged , Nausea/epidemiology , Program Development , Prospective Studies , Quality Assurance, Health Care/methods , Respiratory Insufficiency/epidemiology , Transportation of Patients/statistics & numerical data , Vomiting/epidemiology
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