Effects of task structure and confirmation bias in alternative hypotheses evaluation.

We empirically examined the effectiveness of how the Analysis of Competing Hypotheses (ACH) technique structures task information to help reduce confirmation bias (Study 1) and the portrayal of intelligence analysts as suffering from such bias (Study 2). Study 1 (N = 161) showed that individuals presented with hypotheses in rows and evidence items in columns were significantly less likely to demonstrate confirmation bias, whereas those presented with the ACH-style matrix (with hypotheses in columns and evidence items in rows) or a paragraph of text (listing the evidence for each hypothesis) were not less likely to demonstrate bias. The ACH-style matrix also did not confer any benefits regarding increasing sensitivity to evidence credibility. Study 2 showed that the majority of 62 Dutch military analysts did not suffer from confirmation bias and were sensitive to evidence credibility. Finally, neither judgmental coherence nor cognitive reflection differentiated between better or worse performers in the hypotheses evaluation tasks.

Fed-batch strategies using butyrate for high cell density cultivation of Pseudomonas putida and its use as a biocatalyst.

A mathematically based fed-batch bioprocess demonstrated the suitability of using a relatively cheap and renewable substrate (butyric acid) for Pseudomonas putida CA-3 high cell density cultivation. Butyric acid fine-tuned addition is critical to extend the fermentation run and avoid oxygen consumption while maximising the biomass volumetric productivity. A conservative submaximal growth rate (µ of 0.25 h(-1)) achieved 71.3 g L(-1) of biomass after 42 h of fed-batch growth. When a more ambitious feed rate was supplied in order to match a µ of 0.35 h(-1), the volumetric productivity was increased to 2.0 g L(-1) h(-1), corresponding to a run of 25 h and 50 g L(-1) of biomass. Both results represent the highest biomass and the best biomass volumetric productivity with butyrate as a sole carbon source. However, medium chain length polyhydroxyalkanoate (mcl-PHA) accumulation with butyrate grown cells is low (4 %). To achieve a higher mcl-PHA volumetric productivity, decanoate was supplied to butyrate grown cells. This strategy resulted in a PHA volumetric productivity of 4.57 g L(-1) h(-1) in the PHA production phase and 1.63 g L(-1) h(-1)over the lifetime of the fermentation, with a maximum mcl-PHA accumulation of 65 % of the cell dry weight.