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1.
Heliyon ; 9(9): e20340, 2023 Sep.
Article in English | MEDLINE | ID: mdl-37809541

ABSTRACT

COVID-19 is known to have deleterious effects on different systems such as the respiratory, cardiovascular, central nervous, and gastrointestinal. However, conflicting data about the possible implications for male reproductive health and fertility have been reported. In addition, the long-term consequences of SARS-CoV-2 infection remain unclear. Herein, we report a case of a 42-year-old man with no known co-morbidities and normal baseline semen quality, who subsequently suffered an asymptomatic SARS-CoV-2 infection. Shortly after, the patient developed sudden oligoasthenozoospermia, even reaching azoospermia, which gradually evolved into persistent severe oligonecrozoospermia, accompanied by semen inflammation and oxidative stress. Remarkably, the latter occurred in the absence of urogenital infections, hormonal imbalances, tissue/organ obstruction/damage, medication or drug treatment, smoking, or exposure to toxins/pollutants, radiation, or high temperature. This case constitutes valuable clinical evidence that adds to the current knowledge in the field and highlights the need for further and longer follow-up studies to better understand the putative long-term consequences of SARS-CoV-2 infection on male fertility.

2.
Int J Biometeorol ; 65(8): 1399-1414, 2021 Aug.
Article in English | MEDLINE | ID: mdl-33834291

ABSTRACT

Spermatogenesis is a temperature-dependent process, and high summer temperatures have been linked to lower sperm concentration and count. However, reports describing the association between other meteorological variables and semen quality are scarce. This study evaluated the association between semen quality and temperature, humidity, pressure, apparent temperature (AT), temperature-humidity index (THI), simplified wet-bulb global temperature (sWBGT), and sunshine duration. Semen samples were obtained at the Laboratorio de Andrología y Reproducción (LAR, Argentina), from men undergoing routine andrology examination (n=11657) and computer-assisted sperm analysis (n=4705) following WHO 2010 criteria. Meteorological variables readings were obtained from the Sistema Meteorológico Nacional. Sperm quality parameters were negatively affected in summer when compared to winter. Additionally, there was a significant decrease in sperm kinematics between winter and spring. Branch and bound variable selection followed by multiple regression analysis revealed a significant association between semen quality and meteorological variables. Specifically, changes in sunshine duration and humidity reinforced the prognosis of semen quality. Highest/lowest sunshine duration and humidity quantiles resulted in decreased sperm concentration, count, motility, vitality and membrane competence, nuclear maturity, and sperm kinematics associated to highest sunshine duration and lowest humidity. Findings from this report highlight the relevance of environmental studies for predicting alterations in male reproductive health associated to variations in meteorological variables, especially considering the current climate changes around the planet due to global warming and its consequences for human health.


Subject(s)
Semen Analysis , Sperm Motility , Humans , Male , Retrospective Studies , Sperm Count , Spermatozoa
3.
Reprod Fertil Dev ; 32(7): 648-656, 2020 Apr.
Article in English | MEDLINE | ID: mdl-32156334

ABSTRACT

The aim of this study was to recategorise body mass index (BMI) in order to classify patients according to their risk of semen abnormalities. Patients (n=20563) presenting at an andrology laboratory were classified into five groups according to BMI: underweight (BMI <20kg m-2), normal weight (BMI 20-24.9kg m-2), overweight (BMI 25-29.9kg m-2), obese (BMI 30-39.9kg m-2) and morbidly obese (BMI >40kg m-2). Semen quality was evaluated to determine: (1) differences between groups using analysis of variance (ANOVA); (2) the chances of semen abnormalities (using generalised linear models, Chi-squared tests and odds ratios); (3) reference BMI values with andrological predictive power (multivariate conglomerate analyses and multivariate analysis of variance (MANOVA)); and (4) expected values of abnormalities for each new group resulting from BMI recategorisation. Morbidly obese and underweight patients exhibited the highest decrease in semen quality and had higher chances of semen abnormalities. The smallest number of sperm abnormalities was found at a BMI of 27kg m-2. Four reference values were identified, recategorising BMI into four groups according to their risk of semen abnormalities (from lowest to highest risk): Group1,BMI between 20 and 32kg m-2; Group2, BMI <20 and BMI >32-37kg m-2; Group3, BMI >37-42kg m-2; and Group4, BMI >42kg m-2. A BMI <20 or >32kg m-2 is negatively associated with semen quality; these negative associations on semen quality increase from a BMI >37kg m-2 and increase even further for BMI >42kg m-2. The BMI recategorisation in this study has andrological predictive power.


Subject(s)
Body Mass Index , Infertility, Male/diagnosis , Infertility, Male/epidemiology , Semen Analysis , Adolescent , Adult , Argentina/epidemiology , Asthenozoospermia/epidemiology , Humans , Infertility, Male/physiopathology , Male , Middle Aged , Obesity/epidemiology , Obesity, Morbid/epidemiology , Odds Ratio , Oligospermia/epidemiology , Overweight/epidemiology , Sperm Count , Sperm Motility , Spermatozoa/abnormalities , Teratozoospermia/epidemiology , Thinness/epidemiology
4.
Fertil Steril ; 110(1): 68-75.e4, 2018 07 01.
Article in English | MEDLINE | ID: mdl-29980266

ABSTRACT

OBJECTIVE: To assess the impact of aging on routine semen and computer-assisted sperm analysis (CASA) motility parameters according to the current World Health Organization guidelines; and to evaluate the effect of obesity and lifestyle (alcohol consumption, cigarette smoking) in older men's semen. DESIGN: Blind cross-sectional study. SETTING: Research laboratory and andrology and reproduction laboratory. PATIENT(S): A population of 11,706 men. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Semen analysis: routine (semen volume, sperm concentration and count, motility, vitality, morphology, hypo-osmotic swelling test, round and peroxidase-positive cell concentration) and CASA (straight-line velocity, curvilinear velocity, average path velocity, linearity, straightness, beat cross frequency, wobble, amplitude of lateral head displacement, and mean angular displacement) parameters; and body mass index. RESULT(S): A negative correlation was found between age and routine semen parameters: volume, sperm count, motility, vitality, total motile spermatozoa and normal-motile spermatozoa, round cell concentration, and hypo-osmotic swelling test values. Several CASA variables (straight-line velocity, curvilinear velocity, average path velocity, beat cross frequency, amplitude of lateral head displacement, and mean angular displacement) were also negatively affected. Using 40 years as a cut-off value, significant differences in most parameters correlated to age. In a selected subpopulation of men unexposed to known fertility-compromising factors, the same evaluations were performed, finding some parameters still decreased. Although obesity exerted a significant deleterious effect on older patients' semen quality, alcohol consumption and cigarette smoking mildly affected it. CONCLUSION(S): Male aging, with the contribution of unhealthy conditions, are paramount effectors of sperm quality deterioration.


Subject(s)
Aging/physiology , Infertility, Male/etiology , Life Style , Spermatozoa/cytology , Spermatozoa/physiology , Adolescent , Adult , Age Factors , Aged , Alcohol Drinking/epidemiology , Alcohol Drinking/physiopathology , Cigarette Smoking/adverse effects , Cigarette Smoking/epidemiology , Cross-Sectional Studies , Humans , Infertility, Male/epidemiology , Male , Middle Aged , Obesity/complications , Obesity/epidemiology , Obesity/physiopathology , Semen Analysis , Sperm Count , Sperm Motility , Young Adult
5.
Rev. méd. Córdoba ; 85: 26-9, 1997.
Article in Spanish | LILACS | ID: lil-245262

ABSTRACT

RESUMEN: OBJETIVOS: Evaluar si existen diferencias de gases en sangre arterial de cordón, Apgar, NACS, y evolución neonatal, entre pacientes sometidas a cesáreas electivas con anestesia peridural vs. anestesia general. METODOS: Se estudiaron 66 pacientes, 25 de las cuales fueron sometidas a anestesia peridural, y 41 a anestesia general; se evaluó: Gases arteriales de cordón puntuación de Apgar, NACS, y evolución neonatal de los pacientes, como también las complicaciones maternas. RESULTADOS: Hemos encontrado diferencias estadisticamente significativas en valores de O2 de cordón (15.08ñ6.4 en anestesia peridural, vs.18.89ñ7.3 en anestesia general. p=0.03). Los valores de Apgar de 1', fueron 8.3ñ1.22 en peridural vs. 7.9ñ1.22 en general, p=0.09. CONCLUSION: Si bien hemos hallado diferencias bioquímicas en estos dos grupos, esto no se ha relejado en la evolución neonatal.


Subject(s)
Anesthesia, Epidural , Anesthesia, General , Cesarean Section
6.
Rev. méd. Córdoba ; 85: 26-9, 1997.
Article in Spanish | BINACIS | ID: bin-14810

ABSTRACT

RESUMEN: OBJETIVOS: Evaluar si existen diferencias de gases en sangre arterial de cordón, Apgar, NACS, y evolución neonatal, entre pacientes sometidas a cesáreas electivas con anestesia peridural vs. anestesia general. METODOS: Se estudiaron 66 pacientes, 25 de las cuales fueron sometidas a anestesia peridural, y 41 a anestesia general; se evaluó: Gases arteriales de cordón puntuación de Apgar, NACS, y evolución neonatal de los pacientes, como también las complicaciones maternas. RESULTADOS: Hemos encontrado diferencias estadisticamente significativas en valores de O2 de cordón (15.08ñ6.4 en anestesia peridural, vs.18.89ñ7.3 en anestesia general. p=0.03). Los valores de Apgar de 1, fueron 8.3ñ1.22 en peridural vs. 7.9ñ1.22 en general, p=0.09. CONCLUSION: Si bien hemos hallado diferencias bioquímicas en estos dos grupos, esto no se ha relejado en la evolución neonatal.(AU)


Subject(s)
Anesthesia, General , Anesthesia, Epidural , Cesarean Section
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