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Synthesis of some 4-oxo-delta 2-thiazolin-2-ylhydrazones as potential antiprotozoal agents.
Alves, A J; Leite, A C; De Santana, D P; Beltrao, T M; Coelho, M R; Gayral, P.
Farmaco ; 48(8): 1167-71, 1993 Aug.
Article in English | MEDLINE | ID: mdl-8216678

ABSTRACT

Several 4-oxo-delta 2-thiazolin-2-ylhydrazone derivatives 6 (6-1 - 6-19) derived from the cyclization reaction between the thiosemicarbazones 5 and homologous alpha-chloroacids were prepared. Only compound 6-2 was found to be active against Entamoeba histolytica and Trichomonas vaginalis.


Subject(s)
Antiprotozoal Agents/chemical synthesis , Hydrazones/chemical synthesis , Thiazoles/chemical synthesis , Animals , Antiprotozoal Agents/pharmacology , Entamoeba histolytica/drug effects , Hydrazones/pharmacology , Metronidazole/pharmacology , Microbial Sensitivity Tests , Thiazoles/pharmacology , Trichomonas vaginalis/drug effects
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