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Experimental Study of a Radiopharmaceutical Agent Based on Modified Fatty Acid Labeled with Technetium-99m.
Sazonova, S I; Il'yushenkova, Yu N; Lishmanov, Yu B; Tsibul'nikov, S V; Skuridin, V S; Nesterov, E A; Varlamova, N V; Il'ina, E A; Filimonov, V D; Belyanin, M V; Stepanova, E V; Minin, S M.
Bull Exp Biol Med ; 162(6): 746-749, 2017 Apr.
Article in English | MEDLINE | ID: mdl-28429212

ABSTRACT

Using rat model of coronary occlusion, we studied pharmacokinetics and the efficiency of a new radiopharmaceutical agent 99mTc-PDA-DTPA intended for diagnostics of changes in myocardial metabolism and its analogue 123I-PMPDA. 99mTc-PDA-DTPA was eliminated mostly by the kidneys and maximal concentration in the heart was attained within 60 min after intravenous injection; no accumulation in the area of myocardial infarction was observed. The studied substance was inferior to its analogue 123I-PMPDA by the quality of scintigraphic visualization of the heart.


Subject(s)
Fatty Acids/pharmacokinetics , Myocardial Infarction/diagnostic imaging , Myocardial Perfusion Imaging/methods , Radionuclide Imaging/methods , Radiopharmaceuticals/pharmacokinetics , Technetium/pharmacokinetics , Animals , Coronary Occlusion/surgery , Fatty Acids/chemistry , Heart/diagnostic imaging , Iodine Radioisotopes , Iodobenzenes/chemistry , Iodobenzenes/pharmacokinetics , Kidney/diagnostic imaging , Kidney/metabolism , Liver/diagnostic imaging , Liver/metabolism , Male , Myocardial Infarction/metabolism , Radiopharmaceuticals/chemistry , Rats , Rats, Wistar , Staining and Labeling/methods , Technetium/chemistry , Tissue Distribution
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