[Neurophysiological and psychopharmacological effects of eiconol--a complex of unsaturated fatty acids]. / Neirofiziologicheskie i psikhofiziologicheskie éffekty éikonola--kompleksa nepredel'nykh zhirnykh kislot.

The effect of omega-3 polyunsturated fatty acids on the psychophysiological state of an operator was studied and mechanisms of the drug action were analyzed based on the EEG data. Changes in the psychophysiological and hemodynamic characteristics, EEG, and catecholamine excretion after a 30-day administration of eiconol--a complex of unsaturated fatty acids--in a daily dose of 8 g were studied in a group of 16 middle-aged healthy male operators. It was established that eiconol decreases systolic arterial pressure, reduces adrenalin excretion with urine, imparts the sense of well-being, improves the parameters of activity and the attention stability and concentration, and decreases the level of static tremor. The drug reduces basic anxiety level and motivation to the operator performance, but at the expense of some decrease in the sensomotor coordination. By the pattern of EEG profile changes, including an increase in the theta (5-7 Hz) and beta (15-28 Hz) bands and a decrease in the delta (0.8-2.0 Hz) band, eiconol resembles psychotropic agents of the adrenoblocking and GABA-ergic types, especially benzodiazepine activators.

[The use of enterosorbents for preventing and stopping chronic toxic stress in submariners]. / Ispol'zovanie énterosorbentov dlia profilaktiki i kupirovaniia khronicheskogo toksicheskogo stressa u podvodnikov.

The efficiency of prophylactic intestinal sorbents use (algisorb and activated carbon) to prevent chronic toxic stress was investigated in 20 healthy volunteers (atomic submarine personnel) basing on evaluation of central nervous system functional state, hemodynamics, hepatic detoxicative ability and dynamics of trace elements in urine. It was revealed that intestinal sorbents administration in daily dose of 5 g during 20 days promotes gastrointestinal elimination of toxic compounds (cadmium, bismuth, chrome, molybdenum, lithium). It is accompanied with decrease in organism intoxication evidences: reduction in central nervous system excessive excitation, decrease in functional tension of cardiovascular system, recovery of hepatic detoxicative ability. Algisorb has an advantage over activated carbon that allows to recommend this drug in prophylaxis and arresting of chronic toxic stress in submariners both during interfield period and autonomic sailing.

[The therapeutic efficacy and the effect of gidazepam and fenazepam on the psychophysiological status and on the performance of operators with mental disorders at a neurotic level]. / Terapevticheskaia éffektivnost' i vliianie gidazepama i fenazepama na psikhofiziologicheskoe sostoianie i rezul'tativnost' deiatel'nosti operatorov s psikhicheskimi narusheniiami nevroticheskogo urovnia.

The effect of placebo and gidazepam on the state, psychophysiological predictors of the quality of the operator's performance and its results in individuals with neurotic reactions was studied (test dose 20 mg 7-day course, 40 mg daily, 24 individuals), as well as the effect of gidazepam and phenazepam (42 individuals with neurotic and neurosis-like states; gidazepam test doses 20 and 50 mg, 14-day course, 40 and 100 mg daily; phenazepam test doses 0.5 and 1 mg, 14-day course, daily dose 2 mg). The generally accepted methods of clinical and psychophysiological examination were applied. Gidazepam in the doses under study did not yield to phenazepam in therapeutic activity. A single and a course administration of gidazepam improved the parameters of the psychophysiological state and the efficacy of the operator performance in patients with neurotic reactions and in those with neurotic and neurosis-like states. This makes it possible, whenever necessary, to recommend this drug for the treatment of the indicated disorders in the working operators.

[The biochemical mechanisms of the decrease in work capacity in sailors exposed to high temperatures and the possible means for their pharmacological correction]. / Biokhimicheskie mekhanizmy snizheniia rabotosposobnosti moriakov v usloviiakh vozdeistviia vysokikh temperatur i vozmozhnye puti ee farmakologicheskoi koreektsii.

The studies conducted on experimental animals and volunteers have proved that the increase of adrenalin, histamine, and serotonin ration in blood was caused by hyperthermic conditions. Activation of hormonal systems leads to acceleration of biochemical processes and to reduction of substrates in organs and tissues (such as regenerated glutathione, histidine) which are necessary for normal health status. A conclusion is made that the metabolite depletion of biochemical reactions provoke the reduction of job performance of man in the conditions of hyperthermic influence. Methods of medicamentous therapy are proposed to maintain the normal job performance of seamen in the conditions of unfavourable influence of high temperatures.

[A method for studying the effect of drugs on the psychophysiological status and quality of the performance of operators with different skills by using a microcomputer]. / Metodika izucheniia vliianiia lekarstvennykh sredstv na psikhofiziologicheskoe sostoianie i kachestvo deiatel'nosti operatorov razlichnogo profilia s ispol'zovaniem mikroEVM.

Computer method for evaluating the quality of the motivated operator's performance and psychophysiological status was devised and validated. This method can be used for clinical studies of new drugs.