ABSTRACT
The paper presents a complex psychophysiological analysis of the effect of a combined administration of pantogam and potassium orotate (kalii orotas) on the dynamics of cognitive function in patients with neurotic disorders. The investigation was conducted in an 8-stage consecutive cycle and employed computer-aided diagnostic system. It was established that the combined use of pantogam and potassium orotate produces a positive effect upon the dynamics of restoration of the attention and memory mechanisms in neurotic patients.
Subject(s)
Attention/drug effects , Memory/drug effects , Neurotic Disorders/drug therapy , Nootropic Agents/therapeutic use , Orotic Acid/therapeutic use , Pantothenic Acid/therapeutic use , gamma-Aminobutyric Acid/therapeutic use , Drug Therapy, Combination , Humans , Neurotic Disorders/psychology , Pantothenic Acid/analogs & derivatives , gamma-Aminobutyric Acid/analogs & derivativesABSTRACT
The paper deals with psychophysiological monitoring on an automatic [symbol: see text] phi K-01 psychophysiological diagnosis unit made in Russia. The unit is intended to detect latent and initial manifestations of stress reactions in healthy individuals and to evaluate the efficiency of psychopharmacological therapy and psychotherapy.
Subject(s)
Stress, Psychological/diagnosis , Adolescent , Child , Humans , Monitoring, Physiologic , Neuropsychological Tests , Psychophysiology , Psychotherapy , Stress, Psychological/therapyABSTRACT
Clinical aspects of the neurotropic effect of tranquillizers are considered. The systemic differentiated analysis of the influence of these psychopharmacological agents on the functional characteristics of the neurological status and psychophysiological condition of patients with neurotic disturbances is carried out. Two types of the neurotropic effect of tranquillizers and their selective vegetotropic effect are discussed. The presented results indicate that the neurotropic action of the psychopharmacological agents is of induced medical character.
Subject(s)
Nervous System/drug effects , Tranquilizing Agents/pharmacology , Autonomic Nervous System/drug effects , Autonomic Nervous System/physiology , Cranial Nerves/drug effects , Cranial Nerves/physiology , Humans , Motor Activity/drug effects , Motor Activity/physiology , Nervous System Physiological Phenomena , Psychomotor Performance/drug effects , Psychomotor Performance/physiology , Reflex/drug effects , Reflex/physiology , Sensation/drug effects , Sensation/physiologyABSTRACT
A comprehensive comparative approach was used to assess the effectiveness of the psychophysiological indices as predictors of the effect of tranquilizing therapy with benzodiazepine drugs in neurotic patients. The study resulted in selection of several psychophysiological characteristics most relevant to the prognosis of individual responses to the tranquilizers irrespective of the particular neurosis form. The characteristics are recommended for the routine medical use. Indices of the sensorimotor activity and visual analyzer functional lability are among these.
Subject(s)
Anti-Anxiety Agents/therapeutic use , Benzodiazepines , Adult , Benzodiazepinones/therapeutic use , Diazepam/therapeutic use , Dose-Response Relationship, Drug , Drug Evaluation , Female , Humans , Individuality , Male , Neurotic Disorders/drug therapy , Neurotic Disorders/physiopathology , Neurotic Disorders/psychology , Placebos , Prognosis , Psychophysiology , Time FactorsSubject(s)
Aminoquinolines , Autonomic Nervous System/drug effects , Flicker Fusion/drug effects , Receptors, Cholinergic/drug effects , Adult , Cholinesterase Inhibitors/therapeutic use , Dose-Response Relationship, Drug , Drug Evaluation , Female , Humans , Male , Middle Aged , Neostigmine/therapeutic use , Neurotic Disorders/drug therapy , Neurotic Disorders/physiopathology , Stimulation, ChemicalSubject(s)
Anti-Anxiety Agents , Benzodiazepines , Benzodiazepinones/adverse effects , Flicker Fusion/drug effects , Neurotic Disorders/drug therapy , Vision Disorders/chemically induced , Adult , Autonomic Nervous System/physiopathology , Female , Humans , Male , Middle Aged , Neurotic Disorders/physiopathology , Vision Disorders/diagnosisABSTRACT
A comparative clinical and pharmacological analysis of the neurovegetotropic activity of the tranquilizers phenazepam and diazepam (benzodiazepine derivatives) was carried out in 287 patients with neurotic disturbances. The patients were analyzed for the genesis, structure and nature of vegetative-effector permanent and paroxysmal disorders. The regular characteristics of the interrelationship between the major psychopathological syndrome and the nature of vasovegetative dysfunctions were established. Considering the above, the differential method was used to study the therapeutic time-course of the status of patients treated with the tranquilizers. Phenazepam was shown to have a predominantly sympatheticotropic action. Comparative analysis of the therapeutic response points to a higher effectiveness of phenazepam in cases of the paroxysmal and of diazepam in cases of the permanent nature of vegetative dysfunctions.
