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2.
Tunis Med ; 88(12): 916-9, 2010 Dec.
Article in French | MEDLINE | ID: mdl-21136360

ABSTRACT

BACKGROUND: Lipoleiomyoma of the uterus (LLU) is an extremely rare, benign, uterine tumour. This rare disease was unknown for a long time. Their histogenesis remains controversial. AIM: To describe the clinical and pathological aspects of uterine lipoleiomyoma and to try to specify, by an immunohistochemical study, its degenerative or tumoral nature. METHODS: 7 cases of LLU were identified represented by 2 pure Lipoma and 5 Lipoleiomyoma. We performed an immunohistochemical study including anti-vimentin, anti-smooth muscle actin, anti PS-100, anti-desmin, anti-factor VIII and anti-HMB- 45. The results were correlated with the pathogenesis of this lesion. RESULTS: Immunohistochemical analysis showed an expression of PS 100 only in lipocytes whereas leiomyomatous cells express only smooth muscle actin. CONCLUSION: Our study supports the benign tumoral nature of the fatty uterine lesions. Lipoleiomyomatous cells may originate from the transformation of a totipotent mesenchymal cell and not from a degenerative process.


Subject(s)
Lipoma/pathology , Uterine Neoplasms/pathology , Actins/metabolism , Adult , Female , Humans , Immunohistochemistry , Lipoma/metabolism , Lipoma/surgery , Middle Aged , Retrospective Studies , S100 Proteins/metabolism , Uterine Neoplasms/metabolism , Uterine Neoplasms/surgery
11.
Tunis Med ; 85(5): 430-2, 2007 May.
Article in French | MEDLINE | ID: mdl-17657934

ABSTRACT

Sclerosing stromal tumor (SST) is an uncommon benign tumor of the ovary, representing 2-6% of all stromal ovarian tumors. Comparatively to other fibrothecals tumors, SST is distinct by particular clinical and histological features. A case of SST occurring in 15-year-old female and review of the literature are described in the present article.


Subject(s)
Ovarian Neoplasms/diagnosis , Sex Cord-Gonadal Stromal Tumors/diagnosis , Adolescent , Female , Humans , Laparotomy , Ovarian Neoplasms/pathology , Sex Cord-Gonadal Stromal Tumors/pathology , Tomography, X-Ray Computed
13.
Tunis Med ; 84(7): 454-7, 2006 Jul.
Article in French | MEDLINE | ID: mdl-17039739

ABSTRACT

Inflammatory fibroid polyp is an uncommon and benign submucosal lesion of the gastrointestinal tract. The maximal incidence is in the fifth and sixth decades. The main histological characteristics are diffuse inflammatory infiltrate with eosinophils and highly vascularized fibrocystic stroma. We report a case of 15-year-old patient who underwent emergency surgery because of acute intestinal obstruction as a result of an intussusception. The macroscopical study after segmental ileal resection showed a nodular lesion 3x2x2 cm, arising from the submucosa with an ulcerated surface. The pathologic diagnosis was ileal inflammatory fibroid polyp. Immunohistochemically, the cells reacted with vimentin and CD34. It has no malignant potential although extensive infiltration may occur. The etiology is unknown. We discuss the clinical, the pathological aspects and the possible etiological factors of the inflammatory fibroid polyp.


Subject(s)
Ileal Diseases/complications , Ileal Diseases/diagnosis , Intestinal Polyps/complications , Intestinal Polyps/diagnosis , Intussusception/etiology , Adolescent , Diagnosis, Differential , Female , Humans , Ileal Diseases/pathology , Ileal Diseases/surgery , Immunohistochemistry , Inflammation , Intestinal Polyps/pathology , Intestinal Polyps/surgery , Intussusception/diagnosis , Intussusception/surgery , Treatment Outcome
14.
Tunis Med ; 84(5): 321-3, 2006 May.
Article in French | MEDLINE | ID: mdl-16915786

ABSTRACT

Little information regarding synchronous gastric cancer associated with hepatocellular carcinoma is available and has been sporadically reported. We report a new case of 60 years old patient operated for gastric carcinoma. The radiological investigations revealed a hepatic nodule which correspond to a hepatocellular carcinoma on histological examination. The aim of this study is to clarify the clinicopathologic and therapeutic features of this association.


Subject(s)
Adenocarcinoma/pathology , Carcinoma, Hepatocellular/pathology , Liver Neoplasms/pathology , Neoplasms, Multiple Primary/pathology , Stomach Neoplasms/pathology , Gastrectomy , Hepatectomy , Humans , Male , Middle Aged
15.
Tunis Med ; 84(4): 263-5, 2006 Apr.
Article in French | MEDLINE | ID: mdl-16833000

ABSTRACT

Mesenchymal hamartoma is a rare and benign tumor.. Representing 5 to 8 % of children's hepatic tumors, it is rarely described in adults. Authors report a new case of hepatic mesenchymal hamartoma in a 21-year-old woman, diagnosed after a sudden onser of clinical and biological cholestasis. Abdominal US and CTscan exminations showed a medial liver tumor with cystic formations suggestive of a hydatid cyst. The diagnosis of hepatic mesenchymal hamartoma was based onn hitology of the resected liver specimen. Radiological findings can suggest the diagnosis but only histology can confirm it. Treatment is surgical involving in most of the cases; a wide hepatic resection because of the size of the tumor. Progosis is excellent when complete exeresis is possible.


Subject(s)
Hamartoma/pathology , Liver Diseases/pathology , Adult , Female , Humans
16.
Tunis Med ; 83(5): 311-4, 2005 May.
Article in French | MEDLINE | ID: mdl-16044909

ABSTRACT

Primary intestinal T-cell lymphomas account for about 5% of all primary gastrointestinal lymphomas and are mostly associated with coeliac disease. Intestinal lymphomas are usually discovered during the 4th to 5th decade and constitute an exceptional complication of coeliac disease. This lymphoma is generally a high grade pleomorphic cell lymphoma with large cells. Our case concerned a 30 year old woman with a history of coeliac disease who developed a gastro-enteromesenteric lymphoma. Anatomopathological and immunohistochemical analysis showed an enteropathy associated T-cell lymphoma. We suggest that patients with coeliac disease unresponsive to a gluten free diet or with deteriorating clinical condition be investigated for complications such as enteropathy associated T-cell lymphoma. It is also important to avoid this complication by detecting asymptomatic form of coeliac disease that needs a gluten-free diet.


Subject(s)
Celiac Disease/complications , Intestinal Neoplasms/etiology , Lymphoma, T-Cell/etiology , Adult , Female , Humans , Immunohistochemistry , Intestinal Neoplasms/pathology , Lymphoma, T-Cell/pathology
18.
Tunis Med ; 81(12): 972-5, 2003 Dec.
Article in French | MEDLINE | ID: mdl-14986536

ABSTRACT

In the differential diagnosis of intestinal obstruction, the endometriosis is an uncommon disease, rarely reported preoperatively. Surgical objective is a total resection of endometriomas, to guarantee symptom relief and ovoid recurrence. In elective cases, preoperative GH-RH analogue hormonal treatment makes easier the surgical procedures. Conservative surgery of the ovaries is mandatory in premenopausal patients.


Subject(s)
Endometriosis/complications , Intestinal Obstruction/etiology , Acute Disease , Adult , Endometriosis/surgery , Female , Growth Hormone-Releasing Hormone/analogs & derivatives , Growth Hormone-Releasing Hormone/therapeutic use , Humans , Intestinal Obstruction/pathology , Intestinal Obstruction/surgery
19.
Tunis Med ; 80(4): 228-32, 2002 Apr.
Article in French | MEDLINE | ID: mdl-12416362

ABSTRACT

The Dubin-Johnson syndrome (DJS) is an autosomal recessive liver disorder characterized by a chronic conjugated hyperbilirubinemia a dark greenish appearance of liver tissue, a double peaked sulfobromophthalein clearance curve, and a characteristic lysosomal accumulation of black pigment "melanine-like" in the hepatocytes. Laboratory datas indicated an increased urinary excretion of coproporphrin isomer I and leukotriene metabolites. In an effort to understand the morphological pattern and the pathogenesis of this disease we reviewed four cases of DJS.


Subject(s)
Jaundice, Chronic Idiopathic/genetics , Jaundice, Chronic Idiopathic/physiopathology , Adolescent , Adult , Diagnosis, Differential , Female , Hepatocytes/pathology , Humans , Hyperbilirubinemia/etiology , Male
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