ABSTRACT
BACKGROUND: Inhaled corticosteroids are widely used in the treatment of asthma but their safety on bone density is controversial. AIM: To study in a population of adults with asthma receiving inhaled corticosteroids for long term, the effect of this therapy on bone mineral density. METHODS: Prospective study including 20 asthmatics, aged from 20 to 45 years, treated with inhaled corticosteroids for 12 months or more, with no risk factors for osteoporosis. We compared osteodensitometric parameters in our patients, bone mass and T-score at vertebral and femoral witness to a population matched by age and sex. RESULTS: The average age of our patients was 35.45 ± 5.43 years and the average BMI was 30.03 ± 5.77 kg/m2. The average daily dose of corticosteroid was 925 ± 133.27g of equivalent of beclometasone with an average take of 33.5 ± 21.3 months. The vertebral site bone mass average was 1216 ± 0106 g/cm2 in the studied group and 1201 ± 0099 g/cm2 in the control group without significant difference (p = 0380). At femur, the bone mass average was 1037 ± 0143 g/cm2 in the patient group and 1056 ± 0107 g/cm2 in the control group (p = 0380). We did not find a significant link between bone mineral density and cumulative dose or the duration of taking inhaled corticosteroids, BMI and tobacco. CONCLUSION: Our work confirms like other previous studies the safety of inhaled corticosteroids on bone mineral density.
Subject(s)
Adrenal Cortex Hormones/administration & dosage , Adrenal Cortex Hormones/pharmacology , Asthma/drug therapy , Bone Density/drug effects , Absorptiometry, Photon , Administration, Inhalation , Adrenal Cortex Hormones/adverse effects , Adult , Asthma/metabolism , Asthma/physiopathology , Cohort Studies , Female , Humans , Male , Middle Aged , Osteoporosis/chemically induced , Osteoporosis/epidemiology , Osteoporosis/etiology , Risk Factors , Young AdultABSTRACT
AIMS: To evaluate the prevalence of osteoporosis during inflammatory bowel disease (IBD) and to determine the risk factors. METHODS: We conducted a prospective study that includes IBD patients. For all patients, bone mineral density was measured by dual-energy X-rays absorptiometry. RESULTS: Study has included 50 IBD patients; thirty had Crohn's disease and 20 had ulcerative colitis. The average age of our patients was of 36.4 + 9.9 years. A low osseous mineral density was noted in 21 patients (45%) distributed in 13% of osteoporosis and 32% of osteopenia. Only the age superior to 35 years, the duration of evolution of the disease superior to 10 years and intestinal resection constituted a risk factors of osteoporosis. After adaptation on the age and the intestinal resection the duration of evolution superior to 10 years persisted as risk factor of osteoporosis. The other risk factors: sex, type of IBD, denutrition and corticoids were not incriminated in the low osseous mineral density during IBD. CONCLUSION: These results confirm the necessity of the systematic search of the osteoporosis during IBD with the aim of proposing an early and effective treatment.
Subject(s)
Inflammatory Bowel Diseases/complications , Inflammatory Bowel Diseases/diagnosis , Osteoporosis/diagnosis , Osteoporosis/etiology , Absorptiometry, Photon , Adult , Bone Density , Colitis, Ulcerative/complications , Colitis, Ulcerative/diagnosis , Crohn Disease/complications , Crohn Disease/diagnosis , Female , Humans , Inflammatory Bowel Diseases/epidemiology , Male , Middle Aged , Osteoporosis/epidemiology , Prevalence , Prospective Studies , Risk Factors , Tunisia/epidemiologyABSTRACT
Myositis ossificans circumscripta (MOC) is a rare benign disorder characterized by heterotopic ossification of soft tissues. We report a case in a 21-year-old male who presented with knee pain after strenuous physical activity. Evidence of inflammation of the knee and a hard swelling in the subquadricipital area were the main physical findings. The initial plain radiographs showed a subpatellar soft tissue mass containing flocculent calcifications. Over the next 2 months, the calcific deposits organized into a calcified mass. Magnetic resonance imaging findings were nonspecific, with a mass within the vastus medialis muscle generating low signal on T1 images and high signal on T2 images, without postgadolinium enhancement. Computed tomography showed several calcific deposits arranged in a ring, strongly suggesting MOC. Histological examination of a biopsy specimen confirmed this diagnosis. Alendronate therapy given for 6 months was followed by marked clinical improvement, obviating the need for surgery.
