Subject(s)
Ectodermal Dysplasia/diagnosis , Alopecia/complications , Alopecia/diagnostic imaging , Child , Ectodermal Dysplasia/diagnostic imaging , Female , Genetic Diseases, X-Linked/complications , Genetic Diseases, X-Linked/diagnostic imaging , Humans , Scalp/abnormalities , Scalp/physiopathologyABSTRACT
BACKGROUND: erysipelas is a common infection of the superficial layer of the skin, predominantly caused by groups A ß-hemolytic streptococci. It is an acute infection of the skin and frequently affects the legs. It is common in the elderly and favoured by the associated comorbidities. Its occurrence in young healthy people is rare. AIM: The present study aimed to elucidate factors associated with acute and recurrent erysipelas in a young population. METHODS: We retrospectively analyzed 147 cases of erysipelas admitted to the dermatology department of the Military Hospital of Tunis, Tunisia, over 18 years, identifying factors associated with recurrence. All patients were aged less than 35 years. RESULTS: During the study period, 147 patients were registered with the diagnosis of erysipelas. There were 125 military soldiers and 22 non-military patients. The prevalence of erysipelas was 2.23%. The median age was 25 years. Almost 86.2% of patients were male. The main favorable factors were: obesity (9%), alcoholism (8%), chronic venous insufficiency (6.5%), chronic lymphedema (3%), leg fracture (2%), and diabetes mellitus (1%). The lesions were mostly located in the lower limbs in 94.9%. According to our multivariate analysis, there was an association between recurrence and diabetes mellitus (p=0.02), female sex (p=0.004), onychomycosis (p=0.004), and plantar dyshidrotic eczema (p<0.005). CONCLUSION: Identifying factors associated with recurrent erysipelas in a young population remains essential for proposing primary and secondary prevention measures.
Subject(s)
Diabetes Mellitus , Erysipelas , Adult , Aged , Comorbidity , Diabetes Mellitus/epidemiology , Erysipelas/diagnosis , Erysipelas/epidemiology , Erysipelas/etiology , Female , Hospitalization , Humans , Male , Recurrence , Retrospective StudiesSubject(s)
Lymphoma, Follicular/therapy , Neoplasm Recurrence, Local/drug therapy , Photochemotherapy/methods , Skin Neoplasms/therapy , Administration, Cutaneous , Aminolevulinic Acid/administration & dosage , Aminolevulinic Acid/analogs & derivatives , Back , Humans , Lymphoma, Follicular/diagnosis , Lymphoma, Follicular/pathology , Male , Middle Aged , Neoplasm Recurrence, Local/diagnosis , Radiotherapy , Skin/drug effects , Skin/pathology , Skin/radiation effects , Skin Neoplasms/diagnosis , Skin Neoplasms/pathology , Treatment OutcomeABSTRACT
Hailey-Hailey disease is a rare blistering dermatosis first described in 1939 by the brothers Howard and Hugh Hailey. Its incidence is estimated at 1/50,000. The inheritance is autosomal dominant with complete penetrance, but a variable expressivity in affected family members. Clinically, Hailey-Hailey disease presents between the third and fourth decade as flaccid vesicles and blisters on erythematous skin, giving rise to erosions, fissures, and vegetations. Maceration and superinfections are frequent. The lesions are typically distributed symmetrically within intertriginous regions such as the retroauricular folds, lateral aspects of the neck, axillae, umbilicus, inguinal, and perianal regions. The disease is characterized by a chronic relapsing course with spontaneous remissions and multiple recurrences. Severe disease can be very frustrating and have a major psychological and social impact. Given the dearth of evidence-based guidelines and large clinical trials, the assessment of the efficacy and safety of treatments is difficult. Treatments include topical and systemic agents, and procedural therapy such as lasers and surgery. This review provides a systematic search of the literature with a focus on classical and emerging treatment options for Hailey-Hailey disease.
Subject(s)
Pemphigus, Benign Familial/therapy , Humans , Laser Therapy/methods , Pemphigus, Benign Familial/epidemiology , Pemphigus, Benign Familial/physiopathology , Recurrence , Severity of Illness IndexABSTRACT
Nail psoriasis has variable prevalence and heterogeneous aspects. Many of them could mimic onychomycosis (OM). It has been suggested that patients with nail psoriasis are at high risk of OM. The aim of our study was to determine the epidemiological and clinical characteristics of nail psoriasis and to estimate the frequency and the factors associated with OM in psoriatic patients. The studied group included 163 patients with psoriasis aged 18 years or older. Epidemiological and clinical data, as well as the severity of skin and nails disease by evaluating the Psoriasis Area Severity Index (PASI) and Nail Area Psoriasis Severity Index (NAPSI) scores were specified. Mycological testing was performed for patients with nail alterations. Nail involvement was found in 71.2% of patients. The most common nail alterations were subungual hyperkeratosis and onycholysis. The mean NAPSI score was 11.6. Mycological testing was performed in 104 patients with onychodystrophy. OM was diagnosed in 53% of the cases. Dermatophytes were the most isolated pathogens. OM was associated with male gender, but not with age, NAPSI, or PASI score. Psoriasis is one of the dermatoses that most commonly affect the nail. Available data about the association between nail psoriasis and OM are controversial. However, mycological testing should be routinely performed on psoriatic nails.
