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1.
J Physiol Pharmacol ; 63(4): 381-8, 2012 Aug.
Article in English | MEDLINE | ID: mdl-23070087

ABSTRACT

High garlic dose could exert adverse health properties and grape seed and skin extract (GSSE) exhibit a variety of beneficial effects, even at high dose. In the present study we evaluated the toxic effect of high garlic dose treatment on antioxidant status of the blood compartment and the protective effect of GSSE. Rats were intraperitoneally (i.p.) administered either with garlic extract (5 g/kg bw) or GSSE (500 mg/kg bw) or a combination of garlic and GSSE at the same doses daily during one month. Plasma parameters and erythrocytes antioxidant status were evaluated. Data confirmed that high garlic dose induced anemia and a pro-oxidative state into erythrocytes characterized by increased malondialdehyde (MDA), carbonyl protein and antioxidant enzyme activities as catalase (CAT), peroxidase (POD) and superoxide dismutase (SOD). Garlic also elevated intracellular hydrogen peroxide (H(2)O(2)) and free iron whereas GSSE treatment counteracted almost all garlic deleterious effects. In conclusion, high garlic dose induced a pro-oxidative state into erythrocytes via the Fenton reaction between H(2)O(2) and free iron, and GSSE exerted antioxidant properties.


Subject(s)
Erythrocytes/drug effects , Garlic , Oxidative Stress/drug effects , Plant Extracts/pharmacology , Protective Agents/pharmacology , Vitis , Animals , Calcium/blood , Catalase/blood , Erythrocytes/metabolism , Fruit , Hydrogen Peroxide/blood , Iron/blood , Male , Peroxidase/blood , Protein Carbonylation , Rats , Rats, Wistar , Seeds , Superoxide Dismutase/blood
3.
Eur J Appl Physiol ; 95(5-6): 496-503, 2005 Dec.
Article in English | MEDLINE | ID: mdl-16151829

ABSTRACT

To study the effects of regular football training on basal and exercise induced levels of growth hormone (GH) and insulin-like growth factor (IGF-1), 13 young football players were investigated by a submaximal exercise at the beginning of the sporting season in October (S1), at the middle of the season in January (S2) and at the end in May (S3). At each session, an exercise test on an ergogycle was performed for 25 min, beginning with an incremental exercise to reach 90% of theoretical maximal heart, which was maintained for the last 10 min of the test. Venous blood samples were collected at rest, at the end of the exercise and at 30 and 60 min during the recovery period. Plasma lactate and glucose concentrations increased during exercise with no difference found between sessions. GH level increased with exercise at each session but the response was significantly higher in S1 than in S2 and S3 (P<0.01). The GH area under the curve decreased significantly all along the football season (P<0.01); the IGF-1 level did not significantly change during exercise nor with training. Basal insulin-like growth factor binding protein-3 (IGFBP3) remained stable during the three sessions. Football training decreased significantly the exercise-stimulated GH levels all along the football season but did not have any significant effect on IGF-1 levels or on basal IGFBP3 levels.


Subject(s)
Exercise/physiology , Growth Hormone/blood , Insulin-Like Growth Factor I/metabolism , Physical Education and Training/methods , Adaptation, Physiological , Adolescent , Adult , Blood Glucose , Football , Humans , Insulin-Like Growth Factor Binding Protein 3/blood , Lactic Acid/blood , Longitudinal Studies , Male
4.
East Mediterr Health J ; 9(5-6): 1099-108, 2003.
Article in French | MEDLINE | ID: mdl-16450543

ABSTRACT

We assessed the effects of Ramadan fasting on metabolic control, particularly change of HDL-cholesterol in 25 type 2 diabetic patients treated with diet or oral agents, with good metabolic control. Clinical and biochemical parameters and food intake were evaluated 3 weeks before Ramadan, in the fourth week of Ramadan and 3 weeks after Ramadan.There were no changes in body weight and blood pressure nor any metabolic complications. The mean plasma fasting glucose, serum fructosamin and haemoglobin A1c did not change. We found a negative relation between cholesterol intake during Ramadan and the change of HDL-cholesterol. When cholesterol intake was lower than 400 mg/day, plasma HDL-cholesterol increased by 13% at the end of Ramadan and by 23% 3 weeks after Ramadan.


Subject(s)
Diabetes Mellitus, Type 2/metabolism , Fasting/metabolism , Islam , Administration, Oral , Blood Glucose/metabolism , Blood Pressure , Body Weight , Cholesterol, Dietary/administration & dosage , Cholesterol, HDL/metabolism , Creatinine/metabolism , Diabetes Mellitus, Type 2/drug therapy , Diet Surveys , Energy Intake , Female , Fructosamine/metabolism , Glycated Hemoglobin/metabolism , Humans , Hypoglycemic Agents/therapeutic use , Longitudinal Studies , Male , Middle Aged , Time Factors , Tunisia , Urban Population , Uric Acid/metabolism
5.
(East. Mediterr. health j).
in French | WHO IRIS | ID: who-119373

ABSTRACT

We assessed the effects of Ramadan fasting on metabolic control, particularly change of HDL-cholesterol in 25 type 2 diabetic patients treated with diet or oral agents, with good metabolic control. Clinical and biochemical parameters and food intake were evaluated 3 weeks before Ramadan, in the fourth week of Ramadan and 3 weeks after Ramadan.There were no changes in body weight and blood pressure nor any metabolic complications. The mean plasma fasting glucose, serum fructosamin and haemoglobin A1c did not change. We found a negative relation between cholesterol intake during Ramadan and the change of HDL-cholesterol. When cholesterol intake was lower than 400 mg/day, plasma HDL-cholesterol increased by 13% at the end of Ramadan and by 23% 3 weeks after Ramadan


Subject(s)
Administration, Oral , Blood Glucose , Blood Pressure , Cholesterol, Dietary , Creatinine , Fasting , Fructosamine , Glycated Hemoglobin , Hypoglycemic Agents , Time Factors , Uric Acid , Diabetes Mellitus, Type 2
6.
East Mediterr Health J ; 8(4-5): 603-11, 2002.
Article in French | MEDLINE | ID: mdl-15603043

ABSTRACT

We evaluated the effects of fasting during Ramadan on nutritional intake and plasma lipoproteins in 20 healthy adults of normal weight. A 5-day food questionnaire was completed for every participant. Clinical investigations, anthropometrical measurements and laboratory analysis were also undertaken. Body weight, blood pressure and blood glucose were not influenced by fasting but there were non-significant modifications in the plasma lipid fractions. The total cholesterol remained unchanged. Total daily energy intake was comparable before, during and after Ramadan despite the decrease in meal frequency during fasting. Thus fasting in Ramadan did not affect dietary intake, clinical, anthropometrical and most biological parameters.


Subject(s)
Cholesterol, HDL/blood , Cholesterol, LDL/blood , Energy Intake/physiology , Fasting , Islam , Nutritional Status , Adult , Analysis of Variance , Anthropometry , Blood Glucose/metabolism , Blood Pressure , Body Weight , Fasting/adverse effects , Fasting/physiology , Female , Humans , Male , Middle Aged , Nutrition Assessment , Nutrition Surveys , Prospective Studies , Surveys and Questionnaires , Tunisia
7.
(East. Mediterr. health j).
in French | WHO IRIS | ID: who-119205

ABSTRACT

We evaluated the effects of fasting during Ramadan on nutritional intake and plasma lipoproteins in 20 healthy adults of normal weight. A 5-day food questionnaire was completed for every participant. Clinical investigations, anthropometrical measurements and laboratory analysis were also undertaken. Body weight, blood pressure and blood glucose were not influenced by fasting but there were non-significant modifications in the plasma lipid fractions. The total cholesterol remained unchanged. Total daily energy intake was comparable before, during and after Ramadan despite the decrease in meal frequency during fasting. Thus fasting in Ramadan did not affect dietary intake, clinical, anthropometrical and most biological parameters


Subject(s)
Analysis of Variance , Anthropometry , Blood Glucose , Blood Pressure , Cholesterol, HDL , Cholesterol, LDL , Energy Intake , Islam , Nutrition Assessment , Nutrition Surveys , Nutritional Status , Fasting
8.
Tunis Med ; 77(11): 558-61, 1999 Nov.
Article in French | MEDLINE | ID: mdl-10730142

ABSTRACT

The present work is based upon a prospective in study done in a semi-urban area of suburbs of Tunis, from february to November 1997. A total of 302 children aged between 6 month to 5 years were enrolled in the survey. The study aimed at assessing the extention of parasitoses in preschool aged children. The relationship between the Giardiasis intestinalis and ferropenic anemia. The prevalence of anemia is 31.78% (n = 302). The parasitologic analysis has shown that 113 children out of 302 are infected; 37.41%. We observed an obvious predominance of Giardia Lamblia: 62% (n = 113) pathogenic protozoon. The rate of anemia parasited children is amounted to 19.78%. During the Giardiasis, anemia is present in 23.17% of the cases. The Polyparasitism concerns 16% of the infested children. This anemia could be caused by a global bad absorption syndrome or by a ferro-elective bad absorption. A proper sanitary education, a purification action and also a curative treatment of the beaners carriers will be the only guarantees to decrease its morbidity.


Subject(s)
Anemia/etiology , Child Welfare , Giardiasis/complications , Anemia/epidemiology , Child, Preschool , Female , Giardiasis/epidemiology , Humans , Incidence , Infant , Male , Morbidity , Prevalence , Tunisia/epidemiology
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