Head mounted DMD based projection system for natural and prosthetic visual stimulation in freely moving rats.

Novel technologies are constantly under development for vision restoration in blind patients. Many of these emerging technologies are based on the projection of high intensity light patterns at specific wavelengths, raising the need for the development of specialized projection systems. Here we present and characterize a novel projection system that meets the requirements for artificial retinal stimulation in rats and enables the recording of cortical responses. The system is based on a customized miniature Digital Mirror Device (DMD) for pattern projection, in both visible (525 nm) and NIR (915 nm) wavelengths, and a lens periscope for relaying the pattern directly onto the animal's retina. Thorough system characterization and the investigation of the effect of various parameters on obtained image quality were performed using ZEMAX. Simulation results revealed that images with an MTF higher than 0.8 were obtained with little effect of the vertex distance. Increased image quality was obtained at an optimal pupil diameter and smaller field of view. Visual cortex activity data was recorded simultaneously with pattern projection, further highlighting the importance of the system for prosthetic vision studies. This novel head mounted projection system may prove to be a vital tool in studying natural and artificial vision in behaving animals.

Cortical adaptation and visual enhancement.

Passive ophthalmic optic devices correct refractive defects of the eye but are not designed to employ neural adaptation processes. An extended depth of focus technology is implemented on conventional refractive devices, such as spectacles and contact lenses, and its testing is described. This technology is capable of simultaneously correcting all refractive errors, such as myopia, hyperopia, presbyopia, regular/irregular astigmatism, as well as their combinations. This is achieved by exploiting the capacity of the visual system for adaptation to contrast as well as its capability of creating a coherent continuous visual field out of discrete lines of sight.

Intraocular omni-focal lens with increased tolerance to decentration and astigmatism.

PURPOSE: To measure the optical performance of an extended depth of focus (EDOF) intraocular lens (IOL), which provides an imaging solution for near, intermediate, and distance ranges, and to compare its optical performance to available bifocal IOLs with various extents of decentration and astigmatism aberrations. METHODS: A special profile that performs interference principle-based focal extension is engraved on the top of a monofocal rigid IOL. An optical bench based on the L&B eye model was used to test the performance in comparison with the bifocal AcrySof ReSTOR SA60D3 lens (Alcon Laboratories Inc). RESULTS: The imaging performances at near, intermediate, and distance ranges were mapped. Different decentration parameters and amount of astigmatism aberration were tested. In numerical simulations and the experimental bench, the EDOF IOL was demonstrated to have good visual acuity in near, intermediate, and distance ranges as well as reduced sensitivity to decentration of up to 0.75 mm and the capability of correcting astigmatism aberrations of up to 1.00 diopter. CONCLUSIONS: Extended depth of focus technology is capable of providing clear and focused vision at near, intermediate, and distance ranges. Its high quality imaging is obtained under large decentration conditions and residual astigmatism. This capability broadens the potential use of the technology beyond its application as a simultaneous multifocal lens.

Extending the depth of focus for enhanced three-dimensional imaging and profilometry: an overview.

We overview the benefits that extended depth of focus technology may provide for three-dimensional imaging and profilometry. The approaches for which the extended depth of focus benefits are being examined include stereoscopy, light coherence, pattern projection, scanning line, speckles projection, and projection of axially varied shapes.

Extended depth of focus contact lenses for presbyopia.

The purpose of this Letter is to design, develop, fabricate, and test in clinical trials a new (to our knowledge) type of contact lenses that provides simultaneous near and distance focused vision for presbyopic subjects, including those with up to 2.00 diopters (D) of regular/irregular astigmatism, as an alternative to multifocal contact lenses. The purpose is obtained by generating an optical pattern on the front surface of contact lenses, capable of extending the depth of focus of lenses by 3.00 D with high visual contrast. The pattern was fabricated on top of contact lenses and tested by the use of an eye simulation as well as in clinical trials. Use of the extended depth of focus contact lens enabled patients to achieve good visual acuity and contrast sensitivity for both distance and near vision without compromising the energy distribution or the visual fields.

Optical realization of Viterbi decoder for communication network.

The advantages of optics that include processing speed and information throughput, modularity and versatility could be incorporated into one of the most interesting and applicable topics of digital communication related to Viterbi decoders. We aim to accelerate the processing rate and capabilities of Viterbi decoders applied for convolution codes, speech recognition, inter symbol interference (ISI) mitigation problems. The suggested configuration for realizing the decoder is based upon fast optical switches. The configuration is very modular and can easily be increased to Viterbi decoder based upon state machine with larger number of states and depth of the trellis diagram.

Extended depth of focus imaging with birefringent plate.

In this paper we present a simple approach to obtain extended depth of field for any optical imaging system just by adding a birefringent plate between the lens and the detector. The width of the plate is properly designed such that one polarization state contains in-focus near field information while the other polarization state contains in-focus far field details. Both images are superimposed one on top of the other and thus an all-optical spatially sharp imaging is obtained containing both fields. The width of the plate is also designed such that there is a longitudinal overlapping of the two regions (the near and the far) such that continuously well focused imaging is generated. The presented approach for extending the depth of focus is significantly simple compared to the use of birefringent and bi-focal lenses published recently. Preliminary numerical as well as experimental results verify the proposed approach.

Thin spectacles for myopia, presbyopia and astigmatism insensitive vision.

The aim of the presented research was to develop special spectacles capable of solving common ophthalmic problems as myopia, presbyopia and regular/irregular astigmatism. The method included adapting special all-optical extended depth of focus concept, taken from the field of digital imaging, to ophthalmology, and by that providing the required vision solutions. Special thin mask containing annular like replicated structure (thickness of the structure is less than one micron) was designed and proven to provide extended depth of focus. In this paper we present several experimental results as well as trials with volunteers. The testing included measuring the visual acuity under different illumination conditions (pupil size varied from 2 up to 4mm), as well as stereoscopy, color integrity, field of view and contrast. The results demonstrate improvements of up to 3 Diopters (for presbyopic that require the bifocal or the progressive lens solutions) for pupil sizes of 2-4mm. The approach has demonstrated improvement of more than 2 Diopters for regular as well as irregular astigmatism. The main advantage of the developed optical element is that it is very thin (less than few microns) and has low price, it has high energetic throughput and low chromatic aberrations and it operates over the full field of view while providing continuously focused image (in contrast to bifocal lenses having only 2 focused regions). The element also provides a solution for regular as well as irregular astigmatism that currently has no available treatment.