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5.
Acta Haematol ; 108(1): 39-42, 2002.
Article in English | MEDLINE | ID: mdl-12145466

ABSTRACT

An inversion, inv(4)(p14q27), was found as the sole karyotypic anomaly at diagnosis in the bone marrow cells from a 65-year-old male patient with an M4 acute nonlymphocytic leukemia (ANLL). To our knowledge, the breakpoints observed in this case appear to be different from other inversions of chromosome 4 previously described in ANLL. The patient we described had a poor response to chemotherapy and had a short survival.


Subject(s)
Chromosome Inversion , Chromosomes, Human, Pair 4/ultrastructure , Leukemia, Myelomonocytic, Acute/genetics , Aged , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Bone Marrow/pathology , Chromosomes, Human, Pair 4/genetics , Cytarabine/administration & dosage , Fatal Outcome , Humans , Idarubicin/administration & dosage , Karyotyping , Leukemia, Myelomonocytic, Acute/drug therapy , Male , Mitoxantrone/administration & dosage
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